Fig. 3

Relation between Model and Simulation Domain of Use, Use Capacity and Strength of Influence. Model and Simulation developed for a specific Domain of Use will typically have the greatest Strength of Influence within a commensurate range of Use Capacity. It may, however, be able to provide inference data for other Use Capacity areas. For example, an modeling and simulation framework specifically intended for translational research (blue line) in pharmaceuticals is likely to have the highest Strength of Influence in therapeutics development (e.g. new drug development). Similarly, a highly vetted epidemiological modeling and simulation to analyze the long-term effect(s) of an FDA-approved vaccine on public health (red line) is likely to be most credible for informing healthcare policy and preventative therapeutics implementation. The Strength of Influence of these examples would likely differ should the Use Capacity involve applications related to regulatory approval, therapeutics development, and hypothesis testing