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Table 2 Proteins with increased relative abundance in ME/CFS compared to healthy controls (P < 0.01, Log10(Fold-Change) > 0.2)

From: A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

GI accession Protein name Gene name P- value log10 (fold-Change) Fold-change
148727341 Serine-threonine kinase receptor-associated protein STRAP 0.00019 0.21 1.61
22538467 Proteasome subunit beta type-4 PSMB4 0.00021 0.25 1.77
24371248 FUN14 domain-containing protein 2 FUNDC2 0.00048 0.25 1.80
41281564 WD repeat-containing protein 37 WDR37 0.00049 0.23 1.69
145275202 Isoaspartyl peptidase/l-asparaginase ASRGL1 0.00050 0.21 1.61
148539872 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.00072 0.21 1.62
7705558 Inositol-3-phosphate synthase 1 ISYNA1 0.0011 0.24 1.75
7019419 Nucleolar GTP-binding protein 2 GNL2 0.0013 0.38 2.38
4503165 cullin-3 CUL3 0.0014 0.45 2.80
44680136 d-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0014 0.41 2.60
4502205 ADP-ribosylation factor 4 ARF4 0.0019 0.27 1.86
259155315 Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 0.0022 0.24 1.73
13129110 Methylosome protein 50 WDR77 0.0023 0.24 1.75
4506923 SH2 domain-containing protein 1A SH2D1A 0.0023 0.28 1.90
6912388 Grancalcin GCA 0.0024 0.25 1.79
115270970 Chloride channel CLIC-like protein 1 CLCC1 0.0024 0.24 1.74
5031981 26S proteasome non-ATPase regulatory subunit 14 PSMD14 0.0029 0.32 2.09
188219591 Nucleolysin TIA-1 isoform p40 TIA1 0.0030 0.27 1.85
22035672 Thioredoxin reductase 2, mitochondrial TXNRD2 0.0031 0.34 2.18
5454166 Vesicle transport through interaction with t-SNAREs homolog 1B VTI1B 0.0033 0.29 1.93
7657116 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0033 0.35 2.23
225543288 SUMO-activating enzyme subunit SAE1 0.0035 0.25 1.80
47132595 Phosphate carrier protein, mitochondrial SLC25A3 0.0036 0.32 2.09
28373194 Proteasomal ubiquitin receptor ADRM1 ADRM1 0.0040 0.43 2.69
153251272 Calcineurin-like phosphoesterase domain-containing protein 1 CPPED1 0.0041 0.21 1.61
4505023 Proteasome assembly chaperone 1 PSMG1 0.0050 0.49 3.09
300360515 Actin-related protein 2/3 complex subunit 1A ARPC1A 0.0051 0.23 1.71
183396804 Regulation of nuclear pre-mRNA domain-containing protein 2 RPRD2 0.0056 0.35 2.26
4885375 Histone H1.2 H1-2 0.0058 0.25 1.79
48762926 Periodic tryptophan protein 2 homolog PWP2 0.0064 0.36 2.30
4885373 Histone H1.1 H1-1 0.0065 0.29 1.95
4885379 Histone H1.4 H1-4 0.0068 0.24 1.74
5032087 Splicing factor 3A subunit 1 isoform 1 SF3A1 0.0069 0.20 1.59
15487670 Nuclear RNA export factor 1 isoform 1 NXF1 0.0073 0.21 1.61
4885377 Histone H1.3 H1-3 0.0073 0.26 1.83
330340389 Up-regulated during skeletal muscle growth protein 5 USMG5 0.0088 0.23 1.70
4506741 40S ribosomal protein S7 RPS7 0.0090 0.23 1.69
4885381 Histone H1.5 H1-5 0.0095 0.29 1.94