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Table 2 Proteins with increased relative abundance in ME/CFS compared to healthy controls (P < 0.01, Log10(Fold-Change) > 0.2)

From: A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

GI accession

Protein name

Gene name

P- value

log10 (fold-Change)

Fold-change

148727341

Serine-threonine kinase receptor-associated protein

STRAP

0.00019

0.21

1.61

22538467

Proteasome subunit beta type-4

PSMB4

0.00021

0.25

1.77

24371248

FUN14 domain-containing protein 2

FUNDC2

0.00048

0.25

1.80

41281564

WD repeat-containing protein 37

WDR37

0.00049

0.23

1.69

145275202

Isoaspartyl peptidase/l-asparaginase

ASRGL1

0.00050

0.21

1.61

148539872

Acetyl-CoA acetyltransferase, cytosolic

ACAT2

0.00072

0.21

1.62

7705558

Inositol-3-phosphate synthase 1

ISYNA1

0.0011

0.24

1.75

7019419

Nucleolar GTP-binding protein 2

GNL2

0.0013

0.38

2.38

4503165

cullin-3

CUL3

0.0014

0.45

2.80

44680136

d-beta-hydroxybutyrate dehydrogenase, mitochondrial

BDH1

0.0014

0.41

2.60

4502205

ADP-ribosylation factor 4

ARF4

0.0019

0.27

1.86

259155315

Mitochondrial 2-oxoglutarate/malate carrier protein

SLC25A11

0.0022

0.24

1.73

13129110

Methylosome protein 50

WDR77

0.0023

0.24

1.75

4506923

SH2 domain-containing protein 1A

SH2D1A

0.0023

0.28

1.90

6912388

Grancalcin

GCA

0.0024

0.25

1.79

115270970

Chloride channel CLIC-like protein 1

CLCC1

0.0024

0.24

1.74

5031981

26S proteasome non-ATPase regulatory subunit 14

PSMD14

0.0029

0.32

2.09

188219591

Nucleolysin TIA-1 isoform p40

TIA1

0.0030

0.27

1.85

22035672

Thioredoxin reductase 2, mitochondrial

TXNRD2

0.0031

0.34

2.18

5454166

Vesicle transport through interaction with t-SNAREs homolog 1B

VTI1B

0.0033

0.29

1.93

7657116

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

GAPDHS

0.0033

0.35

2.23

225543288

SUMO-activating enzyme subunit

SAE1

0.0035

0.25

1.80

47132595

Phosphate carrier protein, mitochondrial

SLC25A3

0.0036

0.32

2.09

28373194

Proteasomal ubiquitin receptor ADRM1

ADRM1

0.0040

0.43

2.69

153251272

Calcineurin-like phosphoesterase domain-containing protein 1

CPPED1

0.0041

0.21

1.61

4505023

Proteasome assembly chaperone 1

PSMG1

0.0050

0.49

3.09

300360515

Actin-related protein 2/3 complex subunit 1A

ARPC1A

0.0051

0.23

1.71

183396804

Regulation of nuclear pre-mRNA domain-containing protein 2

RPRD2

0.0056

0.35

2.26

4885375

Histone H1.2

H1-2

0.0058

0.25

1.79

48762926

Periodic tryptophan protein 2 homolog

PWP2

0.0064

0.36

2.30

4885373

Histone H1.1

H1-1

0.0065

0.29

1.95

4885379

Histone H1.4

H1-4

0.0068

0.24

1.74

5032087

Splicing factor 3A subunit 1 isoform 1

SF3A1

0.0069

0.20

1.59

15487670

Nuclear RNA export factor 1 isoform 1

NXF1

0.0073

0.21

1.61

4885377

Histone H1.3

H1-3

0.0073

0.26

1.83

330340389

Up-regulated during skeletal muscle growth protein 5

USMG5

0.0088

0.23

1.70

4506741

40S ribosomal protein S7

RPS7

0.0090

0.23

1.69

4885381

Histone H1.5

H1-5

0.0095

0.29

1.94

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Journal of Translational Medicine

ISSN: 1479-5876

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