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Table 3 Bivariate correlation analysis among regional haplotypes estimated frequency in the population and COVID-19 incidence and mortality

From: Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19

N°cases/100,000 inhabitants

Haplotype

8 March

8 April

3May

24 May

Correlation

P

Correlation

P

Correlation

P

Correlation

P

HLA-A*01:01g-B*08:01g-C*07:01g-DRB1*03:01g

0.34

0.171

0.75

0.0004***

0.74

0.0004***

0.72

0.0008***

HLA-A*02:01g-B*18:01g-C*07:01g-DRB1*11:04g

− 0.33

0.181

− 0.62

0.006**

− 0.63

0.005**

− 0.61

0.007**

HLA-A*30:01g-B*13:02g-C*06:02g-DRB1*07:01g

− 0.18

0.476

− 0.33

0.183

− 0.33

0.175

− 0.30

0.224

HLA-A*29:02g-B*44:03g-C*16:01g-DRB1*07:01g

0.36

0.141

0.48

0.042*

0.51

0.032*

0.52

0.027*

HLA-A*03:01g-B*07:02g-C*07:02g-DRB1*15:01g

0.17

0.502

0.51

0.033*

0.52

0.028*

0.49

0.038*

N°deaths/100,000 inhabitants

Haplotype

8 March

8 April

3 May

24 May

Correlation

P

Correlation

P

Correlation

P

Correlation

P

HLA-A*01:01g-B*08:01g-C*07:01g-DRB1*03:01g

0.24

0.347

0.52

0.026*

0.57

0.013*

0.57

0.014*

HLA-A*02:01g-B*18:01g-C*07:01g-DRB1*11:04g

− 0.28

0.265

− 0.44

0.065

− 0.50

0.034*

− 0.51

0.032*

HLA-A*30:01g-B*13:02g-C*06:02g-DRB1*07:01g

− 0.19

0.441

− 0.25

0.311

− 0.28

0.257

− 0.29

0.239

HLA-A*29:02g-B*44:03g-C*16:01g-DRB1*07:01g

0.31

0.208

0.36

0.137

0.42

0.083

0.43

0.078

HLA-A*03:01g-B*07:02g-C*07:02g-DRB1*15:01g

0.16

0.538

0.36

0.148

0.40

0.098

0.41

0.094

  1. Correlation = Pearson Correlation Coefficiency. Statistical significance P < 0.05
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Journal of Translational Medicine

ISSN: 1479-5876

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