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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients

Fig. 7

MKK3 overexpression contributes in MYC-dependent induction of epithelial-to-mesenchymal transition. a The Pearson correlation plots for the expression of MKK3 (MAP2K3), MYC, and MKK3-MYC interaction and MYC-dependent EMT-inducers EIF5A, EIF5AL1, and SNAI1. b Overexpression of EIF5A, EIF5al1, and SNAI1 correlates with decreased survival of African American TNBC patients. Log-rank p-values are shown. c A working model by which MKK3-mediated MYC activation leads to transcriptional activation of EMT inducers resulting in increased invasion and metastasis in African American TNBC patients

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Journal of Translational Medicine

ISSN: 1479-5876

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