Fig. 4

Genome compartmentalization highlights compartment switching. a Representative HiChIP Contact and Pearson’s matrices of chromosome 7 demonstrating the altered compartmentalisation patterns observed in ΔSTAG2 cells in comparison to STAG2-WT cells. b Eigenvector compartment scores at 50 kb bin sizes highlighting the differences in A/B compartments between WT and ΔSTAG2 cells. c Example region covering Chr7:20-25mb in WT and ΔSTAG2 cells including; eigenvector scores, HiChIP and Pearson’s correlation matrices and CTCF, H3K27ac and H3K27me3 ChIP-Seq tracks, highlighting the differences in compartment status in STAG2-WT and ΔSTAG2 cells