Human platelet lysate to substitute fetal bovine serum in hMSC expansion for translational applications: a systematic review

Guiotto, M.; Raffoul, W.; Hart, A. M.; Riehle, M. O.; di Summa, P. G.

doi:10.1186/s12967-020-02489-4

Table 10 Composition of human platelet lysate reported in literature: growth factors and proteins

From: Human platelet lysate to substitute fetal bovine serum in hMSC expansion for translational applications: a systematic review

First author	Year	Estimated?	Type of Medium	PDGF (ng/ml)	PDGF-AA (ng/ml)	PDGF-AB (ng/ml)	PDGF-BB (ng/mL)	TGF-Beta (ng/ml)	VEGF (ng/ml)	bFGF (ng/ml)	EGF (ng/ml)	BDNF (ng/ml)	IGF-1 (ng/ml)	HGF (ng/ml)	Beta-NFG	Protein Tot (mg/ml)	Albumin (mg/ml)
Barro	2019	Y	hPL			80.00		32.00	0.17	0.40	3.80	100.00	80.00	0.13		58.32	41.00
Barro	2019	Y	I-hPL			125.00		33.00	0.40	0.42	5.90	80.00	80.00	0.25		26.85	17.00
Barro	2019	N	DVI-hPL			8.16		35.17	0.31	0.35	4.70	25.73	35.17	0.24		26.27	16.00
Chen	2018	N	SDPL			45.00	11	75.00	0.40	0.55	0.85	20.00	17.50	0.12		56.00
Chen	2018	N	FTPL			45.00	11	75.00	0.40	0.55	0.85	20.00	17.50	0.12		56.00
Chen	2018	N	GBPL			45.00	11	75.00	0.40	0.55	0.85	20.00	17.50	0.12		56.00
Chen	2018	N	GBHPL			45.00	11	75.00	0.40	0.55	0.85	20.00	17.50	0.12		56.00
Mangum	2017	N	hPL		4.57	17.84	5.24	5.5	0.75	5.5	0.5	5.5		0.5
Bernardi M	2017	N	hPL		0.00	0.03	0.01	0.05	0.00	0.00	0.00		0.00
Bernardi M	2017	N	PR-SRGF		0.01	0.14	0.01	0.04	0.00	0.00	0.00		0.11
Pierce	2017	N	hPL				10.70		0.80	0.20	3.40					54.00
Viau	2017	N	PR-hPL			28.78		55.20	0.65	0.15	1.48		32.55
Viau	2017	N	hPL			28.78		55.20	0.65	0.15	1.48		32.55
Escobar	2016	N	hPL				0.42	0.15	0.00	0.30	0.42		0.00
Shirzad	2016	N	UCB-PL			577.97		56.04		0.06			501.62			90.46
Shirzad	2016	N	PB-PL			391.62		29.31		0.06			325.50			49.14
Suri	2016	Y	hPL	70.00				250.00	0.90		0.20
Suri	2016	Y	PhPL	40.00				210.00	1.20		0.27
Witzeneder	2013	N	hPL p				18.11	32.74		0.36	0.01		33.14			61.20
Witzeneder	2013	N	hPL n				22.14	54.86		0.17	0.01		4.42			7.70
Witzeneder	2013	N	huS				2.38	4.89		0.00	0.01		85.98			66.60
Mojica-Henshaw	2013	N	hPLFreeze/thaw -196/4 °C		21.00	50.00	13.90			0.19	4.40					58.64
Mojica-Henshaw	2013	N	hPL Freeze/thaw -80/4 °C		13.70	43.80	8.70			0.16	3.60						16.12
Shanskii	2013	N	hPL		6.91	3.98	8.20	16.30	0.15				108.70			26.00	42.50
Fekete	2011	N	PL-PCC		239.41	571.73		139.03	0.33	0.50
Crespo-Diaz	2011	N	hPL	10.00				125.00	0.45	0.20	20.00		130.00
Shichinoche	2011	N	hPL				0.14	2.85				0.79		0.00	0.00
Xia	2011	N	hPL			0.00		5.15		0.04			0.00
Schallmoser	2007	N	hPL		7.42	40.46			0.00	0.06	0.19
Doucet	2005	N	hPL			30.89		50.84		0.09			106.67
Doucet	2005	N	PPP			0.24		0.51		0.00			107.41
Mean Values				40.00	36.63	99.06	7.50	57.24	0.40	0.23	2.77	35.82	78.81	0.13	0.00	49.95	26.52
Shanskii	2013	N	FBS		0.14	0.03	0.00	0.85	0.00				64.10			58.64	34.45
Shichinoche	2011	N	FBS				0.14	1.27				0.00		0.00	0.00
Doucet	2005	N	FCS			0.00		6.21		0.00			72.82
Mean Values					0.14	0.01	0.07	2.78	0.00	0.00		0.00	68.46	0.00	0.00	58.64	34.45
Shichinoche	2011	N	FBS-BMSCs cultures				0.00	1.73				0.03		1.72	0.00
Shichinoche	2011	N	hPL-BMSCs cultures				0.00	3.84				0.05		2.55	0.00

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