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Table 6 Multivariate Cox regression analysis of the impact of lncRNA signature and clinicopathological features on OS and DFS in the three NSCLC patient cohorts

From: Identification of a 4-lncRNA signature predicting prognosis of patients with non-small cell lung cancer: a multicenter study in China

Dataset Parameters Overall survival Disease-free survival
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
Training Signature 3.18 (1.62–6.23) 0.001 2.17 (1.35–3.47) 0.001
Age 1.07 (0.78–1.45) 0.401 1.03 (0.76–1.40) 0.845
Gender 1.61 (0.57–4.51) 0.365 1.42 (0.54–3.73) 0.474
TNM stages 1.61 (1.09–2.15) 0.008 1.47 (1.06–2.05) 0.022
Histological types 0.99 (0.61–1.61) 0.965 0.94 (0.58–1.51) 0.783
Tumor sizes 0.91 (0.47–1.73) 0.767 0.86 (0.45–1.64) 0.657
Differentiation 1.18 (0.78–1.78) 0.43 1.12 (0.75–1.68) 0.587
Pleural invasion 1.60 (0.85–3.01) 0.147 1.79 (0.96–3.35) 0.068
Vascular invasion 2.17 (0.75–6.28) 0.154 1.86 (0.65–5.34) 0.248
Smoking history 2.94 (1.15–7.50) 0.024 2.60 (1.09–6.24) 0.032
Fam. cancer hist. 0.58 (0.25–1.37) 0.218 0.53 (0.23–1.25) 0.146
Validation Signature 2.41 (1.47–3.97) 0.001 2.49 (1.53–4.05) <0.001
Age 1.14 (0.87–1.49) 0.359 1.13 (0.87–1.48) 0.349
Gender 0.64 (0.32–1.27) 0.201 0.79 (0.41–1.55) 0.498
TNM stages 1.40 (1.03–1.91) 0.031 1.40 (1.04–1.88) 0.026
Histological types 0.92 (0.62–1.38) 0.697 0.94 (0.63–1.4) 0.763
Tumor sizes 1.41 (0.80–2.49) 0.240 1.27 (0.73–2.23) 0.402
Differentiation 0.89 (0.59–1.32) 0.552 0.88 (0.60–1.31) 0.537
Pleural invasion 1.42 (0.85–2.39) 0.185 1.51 (0.90–2.52) 0.116
Vascular invasion 5.40 (1.73–16.8) 0.004 4.91 (1.59–15.17) 0.006
Smoking history 0.54 (0.28–1.04) 0.064 0.52 (0.27–1.00) 0.050
Fam. cancer hist. 1.22 (0.66–2.28) 0.521 1.48 (0.81–2.70) 0.206
Independent Signature 1.88 (1.15–3.08) 0.012 1.80 (1.14–2.84) 0.012
Age 1.00 (0.70–1.42) 0.988 1.19 (0.86–1.66) 0.294
Gender 0.80 (0.46–1.40) 0.430 0.70 (0.42–1.18) 0.183
TNM stages 1.80 (1.28–2.54) 0.001 1.69 (1.24–2.30) 0.001
Histological types 1.26 (0.74–2.13) 0.395 1.12 (0.69–1.84) 0.640
Tumor sizes 1.78 (1.06–2.97) 0.028 1.92 (1.19–3.09) 0.008
Differentiation 1.66 (1.03–2.66) 0.037 1.81 (1.16–2.83) 0.009
Pleural invasion 1.26 (0.68–2.33) 0.466 1.59 (0.87–2.91) 0.130
Vascular invasion 1.75 (0.39–7.92) 0.468 2.81 (0.79–9.98) 0.110
  1. Italic P values represent the statistic significance
  2. Fam. cancer hist. Family cancer history