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Table 6 Multivariate Cox regression analysis of the impact of lncRNA signature and clinicopathological features on OS and DFS in the three NSCLC patient cohorts

From: Identification of a 4-lncRNA signature predicting prognosis of patients with non-small cell lung cancer: a multicenter study in China

Dataset

Parameters

Overall survival

Disease-free survival

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Training

Signature

3.18 (1.62–6.23)

0.001

2.17 (1.35–3.47)

0.001

Age

1.07 (0.78–1.45)

0.401

1.03 (0.76–1.40)

0.845

Gender

1.61 (0.57–4.51)

0.365

1.42 (0.54–3.73)

0.474

TNM stages

1.61 (1.09–2.15)

0.008

1.47 (1.06–2.05)

0.022

Histological types

0.99 (0.61–1.61)

0.965

0.94 (0.58–1.51)

0.783

Tumor sizes

0.91 (0.47–1.73)

0.767

0.86 (0.45–1.64)

0.657

Differentiation

1.18 (0.78–1.78)

0.43

1.12 (0.75–1.68)

0.587

Pleural invasion

1.60 (0.85–3.01)

0.147

1.79 (0.96–3.35)

0.068

Vascular invasion

2.17 (0.75–6.28)

0.154

1.86 (0.65–5.34)

0.248

Smoking history

2.94 (1.15–7.50)

0.024

2.60 (1.09–6.24)

0.032

Fam. cancer hist.

0.58 (0.25–1.37)

0.218

0.53 (0.23–1.25)

0.146

Validation

Signature

2.41 (1.47–3.97)

0.001

2.49 (1.53–4.05)

<0.001

Age

1.14 (0.87–1.49)

0.359

1.13 (0.87–1.48)

0.349

Gender

0.64 (0.32–1.27)

0.201

0.79 (0.41–1.55)

0.498

TNM stages

1.40 (1.03–1.91)

0.031

1.40 (1.04–1.88)

0.026

Histological types

0.92 (0.62–1.38)

0.697

0.94 (0.63–1.4)

0.763

Tumor sizes

1.41 (0.80–2.49)

0.240

1.27 (0.73–2.23)

0.402

Differentiation

0.89 (0.59–1.32)

0.552

0.88 (0.60–1.31)

0.537

Pleural invasion

1.42 (0.85–2.39)

0.185

1.51 (0.90–2.52)

0.116

Vascular invasion

5.40 (1.73–16.8)

0.004

4.91 (1.59–15.17)

0.006

Smoking history

0.54 (0.28–1.04)

0.064

0.52 (0.27–1.00)

0.050

Fam. cancer hist.

1.22 (0.66–2.28)

0.521

1.48 (0.81–2.70)

0.206

Independent

Signature

1.88 (1.15–3.08)

0.012

1.80 (1.14–2.84)

0.012

Age

1.00 (0.70–1.42)

0.988

1.19 (0.86–1.66)

0.294

Gender

0.80 (0.46–1.40)

0.430

0.70 (0.42–1.18)

0.183

TNM stages

1.80 (1.28–2.54)

0.001

1.69 (1.24–2.30)

0.001

Histological types

1.26 (0.74–2.13)

0.395

1.12 (0.69–1.84)

0.640

Tumor sizes

1.78 (1.06–2.97)

0.028

1.92 (1.19–3.09)

0.008

Differentiation

1.66 (1.03–2.66)

0.037

1.81 (1.16–2.83)

0.009

Pleural invasion

1.26 (0.68–2.33)

0.466

1.59 (0.87–2.91)

0.130

Vascular invasion

1.75 (0.39–7.92)

0.468

2.81 (0.79–9.98)

0.110

  1. Italic P values represent the statistic significance
  2. Fam. cancer hist. Family cancer history