Identification and validation of smoking-related genes in lung adenocarcinoma using an in vitro carcinogenesis model and bioinformatics analysis

Table 2 Association of mRNA expression levels of GYPC, NME1 and SLIT2 with the pathological features

Factor	Case	GYPC	NME1	SLIT2
Gender
Male	238	8.31 ± 0.91	10.95 ± 0.86	7.44 ± 1.57
Female	277	8.52 ± 0.94*	10.80 ± 0.84*	7.63 ± 1.47
Age
< 60	136	8.37 ± 0.99	11.00 ± 0.78	7.32 ± 1.61
\(\ge \)60	360	8.45 ± 0.91	10.82 ± 0.88*	7.63 ± 1.48*
Invasion depth
T1	169	8.63 ± 0.77	10.67 ± 0.88	7.89 ± 1.31
T2	277	8.32 ± 0.99**	10.96 ± 0.76**	7.35 ± 1.57**
T3	47	8.38 ± 0.92	10.97 ± 1.11	7.35 ± 1.69*
T4	19	7.99 ± 0.87**	11.07 ± 0.98	7.34 ± 1.29
Lymph node metastasis
N0	331	8.43 ± 0.95	10.78 ± 0.85	7.58 ± 1.55
N1	96	8.43 ± 0.89	11.04 ± 0.85**	7.34 ± 1.46
N2	74	8.27 ± 0.85	11.10 ± 0.81**	7.47 ± 1.44
N3	2	8.46 ± 0.19	11.04 ± 1.07	6.76 ± 0.46
Distant metastasis
M0	346	8.43 ± 0.92	10.95 ± 0.85	7.50 ± 1.48
M1	25	8.06 ± 0.88	10.96 ± 0.91	7.66 ± 1.70
TNM stage
I	275	8.46 ± 0.92	7.60 ± 1.49	10.78 ± 0.82
II	122	8.47 ± 0.99	7.47 ± 1.59	10.87 ± 0.85
III	84	8.30 ± 0.83	7.36 ± 1.41**	11.12 ± 0.89
IV	26	8.17 ± 1.02	7.78 ± 1.78	10.92 ± 0.91

Note: The data was presented as in log\(_{2}\)(x+1) transformed RSEM normalized count. LUAD, lung adenocarcinoma; TCGA: The Cancer Gene Atlas; TNM: tumor-node-metastasis; stage RSEM: RNA seq by expectation-maximization. * p<0.05, versus the first group of the corresponding feature. ** p<0.01, versus the first group of the corresponding feature

ISSN: 1479-5876