Identification and validation of smoking-related genes in lung adenocarcinoma using an in vitro carcinogenesis model and bioinformatics analysis

Table 1 Association of mRNA expression with LUAD patient tobacco smoking history in the TCGA database

Smoking history	Cases	GYPC	NME1	SLIT2
Smoking history	(N)	(log2(RSEM+1))	(log2(RSEM+1))	(log2(RSEM+1))
1	75	8.64 ± 0.93	10.64 ± 0.98	7.85 ± 1.43
2	119	8.20 ± 1.00**	11.06 ± 0.70**	7.17 ± 1.53**
3	135	8.39 ± 0.82	10.62 ± 0.91^##	7.69 ± 1.50^##
4	168	8.47 ± 0.92^#	10.99 ± 0.80**	7.54 ± 1.55^#

1 = Lifelong Non-smokers (less than 100 cigarettes smoked in Lifetime), 2 = Current smokers (includes daily smokers and non-daily smokers or occasional smokers), 3 = Current reformed smokers for >15 years (greater than 15 years), 4 = Current reformed smokers for \(\le \)15 years (less than or equal to 15 years). Data represented are Mean ± SD, n depend on how many valid LUAD samples with corresponding factors. SD indicates standard deviation. *p < 0.05, versus Lifelong Non-smokers; **p < 0.01, versus Current smokers; ^#p < 0.05, versus Lifelong Non-smokers; ^##p < 0.01, versus Current smokers

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