Table 4 The top 10 GO enrichment terms of genes in each module
From: Identifying the pattern of immune related cells and genes in the peripheral blood of ischemic stroke
GO term ID | Term description | Observed gene count | Background gene count | False discovery rate |
|---|---|---|---|---|
Black module | ||||
 GO:0002376 | Immune system process | 29 | 2370 | 4.39E−08 |
 GO:0006955 | Immune response | 24 | 1560 | 4.39E−08 |
 GO:0002237 | Response to molecule of bacterial origin | 12 | 317 | 3.03E−07 |
 GO:0071345 | Cellular response to cytokine stimulus | 18 | 953 | 3.5E−07 |
 GO:0032496 | Response to lipopolysaccharide | 11 | 298 | 1.13E−06 |
 GO:0019221 | Cytokine-mediated signaling pathway | 14 | 655 | 5.05E−06 |
 GO:0009617 | Response to bacterium | 13 | 555 | 5.46E−06 |
 GO:0010033 | Response to organic substance | 27 | 2815 | 7.47E−06 |
 GO:0007166 | Cell surface receptor signaling pathway | 23 | 2198 | 2.47E−05 |
 GO:0071310 | Cellular response to organic substance | 23 | 2219 | 2.67E−05 |
Blue module | ||||
 GO:0043312 | Neutrophil degranulation | 45 | 485 | 4.58E−29 |
 GO:0002366 | Leukocyte activation involved in immune response | 47 | 616 | 5.58E−28 |
 GO:0045055 | Regulated exocytosis | 48 | 691 | 4.66E−27 |
 GO:0006887 | Exocytosis | 50 | 774 | 5.35E−27 |
 GO:0002443 | Leukocyte mediated immunity | 46 | 632 | 1.14E−26 |
 GO:0006955 | Immune response | 65 | 1560 | 6.26E−26 |
 GO:0002252 | Immune effector process | 52 | 927 | 1.49E−25 |
 GO:0045321 | Leukocyte activation | 50 | 894 | 2.16E−24 |
 GO:0001775 | Cell activation | 51 | 1024 | 8.55E−23 |
 GO:0016192 | Vesicle-mediated transport | 63 | 1699 | 2.08E−22 |
Green module | ||||
 GO:0002252 | Immune effector process | 19 | 927 | 0.0071 |
 GO:0002274 | Myeloid leukocyte activation | 15 | 574 | 0.0071 |
 GO:0002443 | Leukocyte mediated immunity | 16 | 632 | 0.0071 |
 GO:0001775 | Cell activation | 19 | 1024 | 0.009 |
 GO:0002366 | Leukocyte activation involved in immune response | 14 | 616 | 0.009 |
 GO:0002697 | Regulation of immune effector process | 11 | 362 | 0.009 |
 GO:0043312 | Neutrophil degranulation | 13 | 485 | 0.009 |
 GO:0045321 | Leukocyte activation | 18 | 894 | 0.009 |
 GO:0006810 | Transport | 44 | 4130 | 0.0163 |
 GO:0006887 | Exocytosis | 15 | 774 | 0.0163 |
Pink module | ||||
 GO:0051345 | Positive regulation of hydrolase activity | 12 | 742 | 0.0037 |
 GO:0001932 | Regulation of protein phosphorylation | 12 | 1370 | 0.021 |
 GO:0001933 | Negative regulation of protein phosphorylation | 8 | 422 | 0.021 |
 GO:0002252 | Immune effector process | 10 | 927 | 0.021 |
 GO:0002275 | Myeloid cell activation involved in immune response | 9 | 519 | 0.021 |
 GO:0002376 | Immune system process | 18 | 2370 | 0.021 |
 GO:0002444 | Myeloid leukocyte mediated immunity | 9 | 519 | 0.021 |
 GO:0006334 | Nucleosome assembly | 5 | 137 | 0.021 |
 GO:0006810 | Transport | 24 | 4130 | 0.021 |
 GO:0006955 | Immune response | 15 | 1560 | 0.021 |
Purple module | ||||
 GO:0043312 | Neutrophil degranulation | 11 | 485 | 8.96E−07 |
 GO:0006952 | Defense response | 14 | 1234 | 1.28E−06 |
 GO:0002376 | Immune system process | 18 | 2370 | 2.07E−06 |
 GO:0001819 | Positive regulation of cytokine production | 9 | 390 | 2.31E−06 |
 GO:0006955 | Immune response | 15 | 1560 | 2.31E−06 |
 GO:0045321 | Leukocyte activation | 12 | 894 | 2.33E−06 |
 GO:0032940 | Secretion by cell | 12 | 959 | 4.74E−06 |
 GO:0016192 | Vesicle-mediated transport | 15 | 1699 | 5.49E−06 |
 GO:0006950 | Response to stress | 18 | 3267 | 0.00015 |
 GO:0009056 | Catabolic process | 13 | 1859 | 0.00059 |
Turquoise module | ||||
 GO:0006955 | Immune response | 58 | 1560 | 1.55E−14 |
 GO:0002376 | Immune system process | 71 | 2370 | 3.57E−14 |
 GO:0002252 | Immune effector process | 42 | 927 | 8.96E−13 |
 GO:0045087 | Innate immune response | 36 | 676 | 1E−12 |
 GO:0006952 | Defense response | 46 | 1234 | 1.89E−11 |
 GO:0050896 | Response to stimulus | 128 | 7824 | 4.85E−09 |
 GO:0006950 | Response to stress | 73 | 3267 | 9.15E−09 |
 GO:0080134 | Regulation of response to stress | 41 | 1299 | 6.2E−08 |
 GO:0034097 | Response to cytokine | 36 | 1035 | 7.1E−08 |
 GO:0048584 | Positive regulation of response to stimulus | 53 | 2054 | 8.11E−08 |
Yellow module | ||||
 GO:0002684 | Positive regulation of immune system process | 23 | 882 | 4.91E−05 |
 GO:0002250 | Adaptive immune response | 13 | 280 | 8.36E−05 |
 GO:0008284 | Positive regulation of cell population proliferation | 22 | 878 | 8.36E−05 |
 GO:0007166 | Cell surface receptor signaling pathway | 36 | 2198 | 0.00011 |
 GO:0050851 | Antigen receptor-mediated signaling pathway | 9 | 122 | 0.00011 |
 GO:0048584 | Positive regulation of response to stimulus | 34 | 2054 | 0.00014 |
 GO:0048583 | Regulation of response to stimulus | 50 | 3882 | 0.00019 |
 GO:0002376 | Immune system process | 36 | 2370 | 0.00031 |
 GO:0006955 | Immune response | 28 | 1560 | 0.00031 |
 GO:0046649 | Lymphocyte activation | 13 | 358 | 0.00031 |