Fig. 4

Graphs of the CNS tissue concentrations in µg/g tissue and of the expression levels of MALAT1 RNA for the animals in the different groups illustrating the specific comparisons made in the experiment. The CNS tissues are arranged from the tissues closest to the injection site on the left of each graph (lumbar spinal cord) to the most distal from the injection site (frontal cortex) on the right of each graph. Graphs a–c have the ASO tissue concentration data and d–f displays the Malat1 RNA expression values as percent of naïve expression. Graphs a and d display the comparisons between high and low volumes with no percussive wraps; graphs b and e display the comparisons between low volume with and without percussive wraps; graphs c and f display the comparisons between high volume with and without percussive wraps. Graphs g–j display the comparisons between the different treatment paradigms and the naïve Malat1 gene expression levels. The key to the different symbols is on the right of the figure. * P < 0.05 for the specific comparison using a Dunnett’s T-test