Fig. 2
Area under the curve analysis (AUC) of the radioactivity concentration versus time curves from the lumbar, thoracic, and cervical spinal regions and the cranial region of the PET scans. AUC values are in units of %ID/g h. a Image of 64Cu-DOTA PET imaging in the cynomolgus monkey. b Image of the regions of interest superimposed on the CT scan of a cynomolgus monkey. c Comparisons of low (0.4 mL) versus high (1.8 mL) injection volume in the different CNS tissues. d Comparisons between low injection volume versus low injection volume with percussive wrap treatment in the different CNS tissues. e Comparisons between high injection volume and high injection volume with percussive wrap treatment in the different CNS tissues. Data displayed are individual values with a horizontal bar depicting the mean for each group. The P values resulting from the two-sided Welch’s T test are written above each graph and a star (*) designates a P value less than 0.05