Table 4 Preliminary targeted panel—immunology relevance focus
From: A modular framework for the development of targeted Covid-19 blood transcript profiling panels
Module set | Module ID | NCBI Entrez ID | Symbol | Name | Module set functional annotation |
|---|---|---|---|---|---|
A1/S1 | M15.38 | 916 | CD3E | CD3e molecule | T cells |
A1/S2 | M14.49 | 974 | CD79B | CD79b molecule | Gene transcription |
A1/S3 | M14.80 | 3122 | HLA-DRA | Major histocompatibility complex, class II, DR alpha | B cells |
A2/S1 | M9.1 | 3002 | GZMB | Granzyme B | Cytotoxic lymphocytes |
A2/S2 | M13.13 | 4282 | MIF | Macrophage migration inhibitory factor | TBD |
A4/S1 | M16.77 | 3811 | KIR3DL1 | Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 | Antigen presentation |
A5/S1 | M16.95 | 972 | CD74 | CD74 molecule | B cells |
A5/S2 | M16.111 | 27242 | TNFRSF21 | TNF receptor superfamily member 21 | B cells |
A7/S1 | M15.61 | 23166 | STAB 1 | Stabilin 1 | Monocytes |
A8/S1 | M16.30 | 3600 | IL15 | Interleukin 15 | Complement |
A8/S2 | M16.106 | 57823 | SLAMF7 | SLAM family member 7 | TBD |
A10/S1 | M15.102 | 246 | ALOX15 | Arachidonate 15-lipoxygenase | Prostanoids |
A26/S1 | M12.2 | 942 | CD86 | CD86 molecule | Monocytes |
A27/S1 | M12.15 | 608 | CD38 | CD38 molecule | Cell cycle |
A28/S1 | M8.3 | 9636 | ISG15 | ISG15 ubiquitin like modifier | Interferon response |
A28/S2 | M15.64 | 10475 | TRIM38 | Tripartite motif containing 38 | Interferon response |
A28/S3 | M10.1 | 115362 | GBP5 | Guanylate binding protein 5 | Interferon response |
A31/S1 | M16.64 | 1950 | EGF | Epidermal growth factor | Platelet/prostaglandin |
A31/S2 | M15.58 | 2214 | FCGR3A | Fc fragment of IgG receptor IIIa | Monocytes |
A33/S1 | M14.24 | 91 | ACVR1B | Activin A receptor type 1B | Cytokines/chemokines, Inflammation |
A33/S2 | M14.19 | 23765 | IL17RA | Interleukin 17 receptor A | Inflammation |
A34/S1 | M8.2 | 3674 | ITGA2B | Integrin subunit alpha 2b | Platelets, prostanoids |
A35/S1 | M13.3 | 1241 | LTB4R | Leukotriene B4 receptor | Inflammation |
A35/S2 | M12.10 | 51311 | TLR8 | Toll like receptor 8 | Neutrophils, inflammation |
A36/S1 | M16.34 | 2993 | GYPA | Glycophorin A (MNS blood group) | Gene transcription |
A37/S1 | M11.3 | 2623 | GATA1 | GATA binding protein 1 | Erythroid cells |
A38/S1 | M10.4 | 4057 | LTF | Lactotransferrin | Neutrophil activation |
A38/S2 | M16.96 | 56729 | RETN | Resistin | Erythroid cells |