Fig. 2

Mapping Covid-19 blood transcriptome signatures at the module aggregate level. The columns on this heatmap represent samples (Xiong et al. and Ong et al.) or patient cohorts (Altman et al.). Module aggregates (A1–A38) are arranged as rows. The colored spots represent the proportion of transcripts comprising each transcriptional module aggregate found to be differentially expressed compared to control samples. The cutoffs vary from one study to another due to differences in the design and the profiling platforms used. Thus, module aggregate response values range from 100% (all transcripts comprised in the module aggregate increased) to −100% (all decreased). The Xiong et al. dataset comprised one control and three Covid-19 patients and transcript abundance was measured by RNA-seq. The Ong et al. dataset comprised three Covid-19 cases from whom samples were collected serially, and nine uninfected controls [8]. Transcript abundance was measured using a 594 gene standard immune panel from Nanostring. Patterns are also shown for cohorts comprised in the Altman et al. dataset [7]. The colored labels (right) indicate functional associations for some of the aggregates