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Table 2 Summary of study characteristics

From: A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease

Author Year Study design Dx Sample sizes Method of analysis
ME/CFS/SEID HCs
Armstrong et al. 2015 Observational case–control Canadian criteria 34 25 NMR spectroscopy
Billing-Ross et al. 2016 Observational case–control Fukuda criteria 193 196 Illumina sequencing
Booth et al. 2012 Observational case–control Fukuda criteria 138 53 ATP profile test
Castro-Marrero et al. 2013 Observational case–control Fukuda criteria 23 15 Western blot bioluminescence
assay
Germain et al. 2017 Observational case–control Fukuda criteria
IOM 2015
17 15 Mass spectrometry
Light et al. 2013 Observational case–control Fukuda criteria 39 22 Real time QPCR
Maes et al. 2009 Observational case–control Fukuda criteria 58 22 High Performance Liquid Chromatography
Mandarano et al. 2019 Observational case–control Canadian criteria 53 45 Seahorse XFe96,
Flow cytometry,
Confocal microscopy
Missailidis et al. 2020A Observational case–control Canadian criteria 51 22 MitoTracker Green FM,
Seahorse XFe24 (mitochondrial stress test)
Missailidis et al. 2020B Observational case–control Canadian criteria 51 22 Seahorse XFe24 (mitochondrial stress test),
XF Glycolysis stress test
Naviaux et al. 2016 Observational case–control Canadian criteria
Fukuda criteria
IOM 2015
45 39 Hydrophilic interaction liquid chromatography, electrospray ionization, and tandem mass spectrometry
Nguyen et al. 2016 Observational case–control Fukuda criteria 17 19 Flow cytometry
Nguyen et al. 2019 Observational case–control Fukuda criteria
International Consensus
criteria
6 6 Seahorse XFp
Plioplys and Plioplys 1995 Observational case–control Fukuda criteria 15 15 Electron microscopy
Shungu et al. 2012 Observational case–control Fukuda criteria 15 13 Magnetic resonance spectroscopy
Sweetman et al. 2019 Observational case–control Canadian criteria 10 10 RNA sequencing
Tomas et al. 2017 Observational case–control Fukuda criteria 52 35 Seahorse XFp
Venter et al. 2019 Observational case–control Fukuda criteria UK: 89 moderate, 29 severe
RSA: 143 moderate
UK: 64
RSA:98
DNA sequencing
Yamano et al. 2016 Observational case–control Fukuda criteria Training: 47
Validation: 20
Training: 46
Validation: 20
Agilent CE capillary electrophoresis system
  1. ATP adenosine triphosphate, DNA deoxyribonucleic acid, HCs healthy controls, IOM Institute of Medicine, ME/CFS/SEID myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease, NMR nuclear magnetic resonance, QPCR quantitative polymerase chain reaction, RSA Republic of South Africa; RNA ribonucleic acid, UK United Kingdom
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