Fig. 4
SARS-CoV-2, Main proteinase 3CLpro analysis. a Cartoon representation structure of the SARS-CoV-2 3CLpro homodimer with inhibitor (green) in greyish black colour. Variant positions of amino acids in 3CLpro (Thr35Val, Ala46Ser, Ser65Asn, Leu86Val, Arg88Lys, Ser94Ala, His134Phe, Lys180Asn, Leu202Val, Ala267Ser, Thr285Ala and Ile286Leu) are shown in yellow colours. b Multiple sequence alignment between SARS-CoV and SARS-CoV-2 3CLpro from Wuhan (Wu) and United States of America (US) patients sharing more than 90% sequence identity. c Surface view representation of SARS-CoV-2 3CLpro (PDB ID: 6Y2G) showing muted amino acid residues in yellow and alpha-ketoamide inhibitor (green) in the substrate binding region. Images are generated by UCSF Chimera software