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Table 2 Functional annotation of identified motifs and their functional gene ontology based conserved domain identification among all the selected corona virus spike proteins

From: Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine development

Sl. no.

Motif width

Function annotation through BLAST

Percent identity in BLAST (%)

Percent identity with the accession no.

Functional gene ontology based domain identification by interproscan

1

49

Spike protein [Human betacoronavirus 2c EMC/2012]

75.51

AGO06003.1

IPR002552 (CORONA_S2), PF01601 (CORONA_S2)

2

50

Spike structural protein [Longquan Aa mouse coronavirus]

91.84

AID16631.1

IPR002552 (Corona_S2), PF01601 (CORONA_S2), SSF111474 (Coronavirus _S2 glycoprotein)

3

41

Spike glycoprotein S [SARS coronavirus BJ182-4]

85.00

ACB69883.1

4

50

Spike glycoprotein [Middle East respiratory syndrome-related coronavirus]

74.00

AOR17480.1

5

50

Spike protein [Human coronavirus NL63]

64.00

AAY43188.1

IPR002552 (Corona_S2), PF01601 (CORONA_S2),

6

34

Spike protein [Bat SARS-like coronavirus]

73.53

AVP78031.1

7

25

Spike protein [Human coronavirus OC43]

88.00

AWW13559.1

Not detected

  1. Interproscan result: Biological process involved: membrane fusion (GO:0061025), receptor-mediated virion attachment to host cell (GO:0046813)
  2. Cellular components: viral envelope (GO:0019031), integral component of membrane (GO:0016021)