Phase | Method | Molecular phenotype | Last-cycle 6-MP DIP | Sensitivity | Specificity | PPV | NPV | Accuracy | ||
---|---|---|---|---|---|---|---|---|---|---|
≤ 25% | > 25% | Total | ||||||||
Discovery | CPIC NUDT15 and TPMT metabolizer | PM + IM | 10 | 46 | 56 | 0.526 | 0.796 | 0.179 | 0.952 | 0.775 |
NM | 9 | 179 | 188 | |||||||
GVBNUDT15,TPMT | ≤ 0.3 | 10 | 42 | 52 | 0.526 | 0.813 | 0.192 | 0.953 | 0.791 | |
> 0.3 | 9 | 183 | 192 | |||||||
GVBNUDT15,TPMT,CRIM1 | ≤ 0.3 | 11 | 32 | 43 | 0.579 | 0.858 | 0.256 | 0.960 | 0.836 | |
> 0.3 | 8 | 193 | 201 | |||||||
Total | 19 | 225 | 244 | |||||||
Replication | CPIC NUDT15 and TPMT metabolizer | PM + IM | 13 | 11 | 24 | 0.520 | 0.784 | 0.542 | 0.769 | 0.697 |
NM | 12 | 40 | 52 | |||||||
GVBNUDT15,TPMT | ≤ 0.3 | 13 | 10 | 23 | 0.520 | 0.804 | 0.565 | 0.774 | 0.711 | |
> 0.3 | 12 | 41 | 53 | |||||||
GVBNUDT15,TPMT,CRIM1 | ≤ 0.45 | 16 | 10 | 26 | 0.640 | 0.804 | 0.615 | 0.820 | 0.750 | |
> 0.45 | 9 | 41 | 50 | |||||||
Total | 25 | 51 | 76 | |||||||
Combined | CPIC NUDT15 and TPMT metabolizer | PM + IM | 23 | 57 | 80 | 0.523 | 0.794 | 0.288 | 0.913 | 0.756 |
NM | 21 | 219 | 240 | |||||||
GVBNUDT15,TPMT | ≤ 0.3 | 23 | 52 | 75 | 0.523 | 0.811 | 0.307 | 0.914 | 0.772 | |
> 0.3 | 21 | 224 | 245 | |||||||
GVBNUDT15,TPMT,CRIM1 | ≤ 0.45 | 28 | 60 | 88 | 0.636 | 0.783 | 0.318 | 0.931 | 0.763 | |
> 0.45 | 16 | 216 | 232 | |||||||
Total | 44 | 276 | 320 |