Table 3 Prediction accuracies of CRIM1 rs3821169 variant for thiopurine toxicity measured by the tolerated last-cycle 6-MP DIP in pediatric ALL subjects with both wild-type NUDT15 and TPMT
Phase | rs3821169 homozygote carriers | DIP | Sensitivity | Specificity | PPV | NPV | Accuracy | ||
|---|---|---|---|---|---|---|---|---|---|
≤ 25% | > 25% | Total | |||||||
Discovery | (+) | 2 | 7 | 9 | 0.222 | 0.961 | 0.222 | 0.961 | 0.926 |
(−) | 7 | 172 | 179 | ||||||
Total | 9 | 179 | 188 | ||||||
Replication | (+) | 3 | 0 | 3 | 0.250 | 1.000 | 1.000 | 0.816 | 0.827 |
(−) | 9 | 40 | 49 | ||||||
Total | 12 | 40 | 52 | ||||||
Combined | (+) | 5 | 7 | 12 | 0.238 | 0.968 | 0.417 | 0.930 | 0.904 |
(−) | 16 | 212 | 228 | ||||||
Total | 21 | 219 | 240 | ||||||