Fig. 3

Improvement prediction accuracies for thiopurine toxicity by introducing CRIM1 into the well-established NUDT15 and TPMT in 320 pediatric ALL subjects. Prediction accuracies (measured in AUCs) for the last-cycle 6-MP DIP of the three-gene model (NUDT15, TPMT and CRIM1) (right panels) outperformed the traditional two-gene model (NUDT15 and TPMT) (left panels) across all seven DIP cutoffs (≤ 15%, ≤ 25%, ≤ 35%, ≤ 45%, ≤ 60%, ≤ 80%, and ≤ 100%) in the discovery (N = 244), replication (N = 76), and combined (N = 320) pediatric ALL cohorts. 95% confidence intervals are in square brackets. GVB, gene-wise variant burden; AUC, area under the receiver operating characteristic curve