Fig. 2

Detection of Orthotopic Pancreatic PDX Tumor by MRI. Yellow: Pancreas; Blue: Tumor. T1-weighted pre-contrast (a), post-contrast (b), and T2-weighted (c) magnetic resonance images of coronal cross sections of the mouse demonstrate successful orthotopic implantation of Patient 1275 PDX tissue into the mouse pancreas. The high signal intensity of the tumor in the T1-weighted post-contrast image indicates high levels of vascularization. The high intensity regions in the T2-weighted image of the pancreas and the tumor suggest the increased presence of fluid