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Table 4 Univariate and multivariate analysis of the p16-positive subgroup

From: Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma

CharacteristicsProgression-free survivalOverall survival
UnivariateUnivariateMultivariate
p valuep valuep valueHazard ratio (95% CI)
Sex0.9230.276  
Age0.8050.6  
Smoking history0.5190.179  
Surgical margina0.8470.738  
Lymphovascular invasiona0.7930.474  
Perineural invasiona0.4380.061  
HPV type
 Type 16 vs. other than 160.0610.185  
8th AJCC stage0.3330.047*0.234 
 Stage II vs. I  0.1143.071 (0.763–12.358)
 Stage III vs. I  0.1783.471 (0.568–21.196)
ERα expression0.2370.006*0.037*0.109 (0.014–0.871)
p53 expression0.1920.054  
  1. HPV human papillomavirus, AJCC American Joint Committee on Cancer, ERα estrogen receptor
  2. *p < 0.05
  3. aEvaluated only in 80 surgical resection specimens
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