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Table 4 Univariate and multivariate analysis of the p16-positive subgroup

From: Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma

Characteristics

Progression-free survival

Overall survival

Univariate

Univariate

Multivariate

p value

p value

p value

Hazard ratio (95% CI)

Sex

0.923

0.276

  

Age

0.805

0.6

  

Smoking history

0.519

0.179

  

Surgical margina

0.847

0.738

  

Lymphovascular invasiona

0.793

0.474

  

Perineural invasiona

0.438

0.061

  

HPV type

 Type 16 vs. other than 16

0.061

0.185

  

8th AJCC stage

0.333

0.047*

0.234

 

 Stage II vs. I

  

0.114

3.071 (0.763–12.358)

 Stage III vs. I

  

0.178

3.471 (0.568–21.196)

ERα expression

0.237

0.006*

0.037*

0.109 (0.014–0.871)

p53 expression

0.192

0.054

  
  1. HPV human papillomavirus, AJCC American Joint Committee on Cancer, ERα estrogen receptor
  2. *p < 0.05
  3. aEvaluated only in 80 surgical resection specimens
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Journal of Translational Medicine

ISSN: 1479-5876

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