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Table 3 Univariate and multivariate analysis of the total patient cohort

From: Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma

CharacteristicsProgression-free survivalOverall survival
UnivariateMultivariateUnivariateMultivariate
p valuep valueHazard ratio (95% CI)p valuep valueHazard ratio (95% CI)
Sex0.925  0.422  
Age0.746  0.23  
Smoking history0.265  0.037*0.41 
Surgical margina0.472  0.537  
Lymphovascular invasiona0.363  0.96  
Perineural invasiona0.503  0.089  
p16/HPV status< 0.001*0.001* < 0.001*0.002* 
 p16+/HPV− vs. p16+/HPV+ 0.0283.526 (1.142–10.885) 0.0037.054 (1.912–26.016)
 p16− vs. p16+/HPV+ < 0.0014.334 (1.993–9.427) 0.0045.616 (1.741–18.121)
8th AJCC stage0.004*0.379 < 0.001*0.016* 
 Stage II vs. I    0.1512.428 (0.724–8.140)
 Stage III vs. I    0.00110.662 (2.508–45.333)
 Stage IV vs. I    0.1073.404 (0.766–15.123)
ERα expression0.044*0.406 0.002*0.107 
ESR1 mRNA expression0.116  0.068  
p53 expression0.001*0.856 0.002*0.101 
  1. HPV human papillomavirus, AJCC American Joint Committee on Cancer, ERα estrogen receptor, ESR1 estrogen receptor 1
  2. *p < 0.05
  3. aEvaluated only in 80 surgical resection specimens
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