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Table 3 Univariate and multivariate analysis of the total patient cohort

From: Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma

Characteristics

Progression-free survival

Overall survival

Univariate

Multivariate

Univariate

Multivariate

p value

p value

Hazard ratio (95% CI)

p value

p value

Hazard ratio (95% CI)

Sex

0.925

  

0.422

  

Age

0.746

  

0.23

  

Smoking history

0.265

  

0.037*

0.41

 

Surgical margina

0.472

  

0.537

  

Lymphovascular invasiona

0.363

  

0.96

  

Perineural invasiona

0.503

  

0.089

  

p16/HPV status

< 0.001*

0.001*

 

< 0.001*

0.002*

 

 p16+/HPV− vs. p16+/HPV+

 

0.028

3.526 (1.142–10.885)

 

0.003

7.054 (1.912–26.016)

 p16− vs. p16+/HPV+

 

< 0.001

4.334 (1.993–9.427)

 

0.004

5.616 (1.741–18.121)

8th AJCC stage

0.004*

0.379

 

< 0.001*

0.016*

 

 Stage II vs. I

    

0.151

2.428 (0.724–8.140)

 Stage III vs. I

    

0.001

10.662 (2.508–45.333)

 Stage IV vs. I

    

0.107

3.404 (0.766–15.123)

ERα expression

0.044*

0.406

 

0.002*

0.107

 

ESR1 mRNA expression

0.116

  

0.068

  

p53 expression

0.001*

0.856

 

0.002*

0.101

 
  1. HPV human papillomavirus, AJCC American Joint Committee on Cancer, ERα estrogen receptor, ESR1 estrogen receptor 1
  2. *p < 0.05
  3. aEvaluated only in 80 surgical resection specimens
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Journal of Translational Medicine

ISSN: 1479-5876

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