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Table 1 Association of clinical factors and the risk of acute oral mucositis

From: Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis

Characteristics Oral mucositis P OR 95% CI
Grade ≥ 3 Grade ≤ 2
Number of patients 349 (23.79%) 1118 (76.21%)    
Age (Mean ± SD) 45.12 ± 10.71 45.18 ± 10.94 0.934 1.00 0.99–1.01
Gender 0.524   
 Male 258 807  
 Female 91 311   0.92 0.69–1.20
Clinical stage 0.047   
 I–II 71 286  
 III–IV 278 832   1.35 1.00–1.81
Tumor stagea 0.035   
 1–2 85 338  
 3–4 264 780   1.35 1.02–1.77
Radiation technique < 0.001   
 2D-CRT 112 641  
 IMRT 237 477   2.84 2.21–3.67
Treatment scheme < 0.001   
 RT alone 24 325  
 RT + IC/AC 15 190 0.845 1.07 0.55–2.09
 CCRT 310 603 < 0.001 6.96 4.50–10.77
  1. 95% CI, 95% confidence interval; SD, standard deviation; 2D-CRT, two-dimensional conventional radiotherapy; IMRT, intensity modulated radiation therapy; RT, radiotherapy; RT + IC/AC, Radiotherapy with induction chemotherapy and/or adjuvant chemotherapy; CCRT, Concurrent chemoradiotherapy
  2. aThe patients were staged according to the 2009 7th UICC/AJCC staging system
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