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Table 1 Association of clinical factors and the risk of acute oral mucositis

From: Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis

Characteristics

Oral mucositis

P

OR

95% CI

Grade ≥ 3

Grade ≤ 2

Number of patients

349 (23.79%)

1118 (76.21%)

   

Age (Mean ± SD)

45.12 ± 10.71

45.18 ± 10.94

0.934

1.00

0.99–1.01

Gender

0.524

  

 Male

258

807

 

–

–

 Female

91

311

 

0.92

0.69–1.20

Clinical stage

0.047

  

 I–II

71

286

 

–

–

 III–IV

278

832

 

1.35

1.00–1.81

Tumor stagea

0.035

  

 1–2

85

338

 

–

–

 3–4

264

780

 

1.35

1.02–1.77

Radiation technique

< 0.001

  

 2D-CRT

112

641

 

–

–

 IMRT

237

477

 

2.84

2.21–3.67

Treatment scheme

< 0.001

  

 RT alone

24

325

 

–

–

 RT + IC/AC

15

190

0.845

1.07

0.55–2.09

 CCRT

310

603

< 0.001

6.96

4.50–10.77

  1. 95% CI, 95% confidence interval; SD, standard deviation; 2D-CRT, two-dimensional conventional radiotherapy; IMRT, intensity modulated radiation therapy; RT, radiotherapy; RT + IC/AC, Radiotherapy with induction chemotherapy and/or adjuvant chemotherapy; CCRT, Concurrent chemoradiotherapy
  2. aThe patients were staged according to the 2009 7th UICC/AJCC staging system