Table 1 C/T concentration variations measured using the ex vivo model
Group | Ceftolozane | Tazobactam | ||
|---|---|---|---|---|
8-h variation (%) | Dunnett test value | 8-h variation (%) | Dunnett test value | |
Low concentration | ||||
T0–T8 | − 4.28 | 0.391 | − 11.20 | 0.019 |
T8–T16 | − 2.63 | 0.433 | − 12.95 | 0.524 |
T16–T24 | − 4.00 | 0.773 | − 7.51 | 0.441 |
Control | − 1.94 | − 11.74 | ||
High concentration | ||||
T0–T8 | − 5.73 | 1.146 | − 2.89 | 1.295 |
T8–T16 | − 3.99 | 1.147 | − 6.75 | 0.340 |
T16–T24 | 1.26 | 0.260 | − 9.72 | 0.693 |
Control | 1.33 | − 5.14 | ||