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Table 1 C/T concentration variations measured using the ex vivo model

From: Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

GroupCeftolozaneTazobactam
8-h variation (%)Dunnett test value8-h variation (%)Dunnett test value
Low concentration
 T0–T8− 4.280.391− 11.200.019
 T8–T16− 2.630.433− 12.950.524
 T16–T24− 4.000.773− 7.510.441
 Control− 1.94 − 11.74 
High concentration
 T0–T8− 5.731.146− 2.891.295
 T8–T16− 3.991.147− 6.750.340
 T16–T241.260.260− 9.720.693
 Control1.33 − 5.14 
  1. Ceftolozane/tazobactam concentration variations measured in low and high concentration groups during the T0–T8, T8–T16 and T16–T24 inter-dose intervals and in the control glass tubes