Fig. 1
From: Antifibrotic therapy to normalize the tumor microenvironment
Treatment strategies against tumor fibrosis. Three main approaches of antifibrotic cancer therapy are currently being investigated: (I) targeting the extracellular matrix (ECM), (II) targeting cancer-associated fibroblasts (CAFs), and (III) targeting profibrotic signaling pathways. Collagen, hyaluronan, and fibronectin are major constituents of the extracellular matrix. Lysyl oxidase (LOX) is a major contributor to the stiffness of the tumor stroma