| Derivation cohort (n = 61) | Validation cohort (n = 54) | p value |
---|---|---|---|
Characteristics | Â | Â | Â |
Age, years | 40 (1–86) | 45 (1–92) | 0.983 |
Gender | Â | Â | 0.268 |
 Male | 31 (50.8) | 33 (61.1) |  |
 Female | 30 (49.2) | 21 (38.9) |  |
Current smoking | 4 (6.6) | 6 (11.1) | 0.387 |
Drinking | 13 (21.3) | 12 (22.2) | 0.906 |
Exposure | Â | Â | Â |
 Wuhan residents come to Beijing | 44 (72.1) | 10 (18.5) | < 0.0001 |
Comorbidity | Â | Â | Â |
 Diabetes | 5 (8.2) | 5 (9.3) | 0.840 |
 Hypertension | 12 (19.7) | 13 (24.1) | 0.568 |
 Cardiovascular disease | 1 (1.6) | 3 (5.6) | 0.253 |
 Chronic obstructive pulmonary disease | 5 (8.2) | 1 (1.9) | 0.127 |
Disease type on admission this hospital | Â | Â | 0.071 |
 Mild | 5 (8.2) | 9 (16.7) |  |
 Moderate | 39 (63.9) | 25 (46.3) |  |
 Severe | 14 (23.0) | 15 (27.8) |  |
 Critical | 3 (4.9) | 5 (9.3) |  |
Signs and symptoms | Â | Â | Â |
 Highest temperature,  °C |  |  |  |
  37.3–38.0 | 21 (34.4) | 13 (24.1) | 0.225 |
  38.1–39.0 | 34 (55.7) | 25 (46.3) | 0.312 |
  > 39.0 | 5 (8.2) | 4 (7.4) | 0.875 |
 Dyspnea | 3 (4.9) | 4 (7.4) | 0.577 |
 Mild shortness of breath | 7 (11.5) | 12 (22.2) | 0.121 |
 Cough | 39 (63.9) | 38 (70.4) | 0.464 |
 Sputum production | 27 (44.3) | 22 (40.7) | 0.703 |
 Fatigue | 35 (57.4) | 26 (48.1) | 0.322 |
 Headache | 21 (34.4) | 6 (11.1) | 0.003 |
 Chill | 12 (19.7) | 9 (16.7) | 0.677 |
 Anorexia | 8 (13.1) | 6 (11.1) | 0.743 |
 Nausea or vomiting | 5 (8.2) | 5 (9.3) | 0.840 |
 Diarrhea | 6 (9.8) | 2 (3.7) | 0.197 |
 Sore throat | 10 (16.4) | 8 (14.8 | 0.816 |
 Chest pain | 1 (1.6) | 0 (0) | 0.345 |
 Systolic pressure < 90 or diastolic pressure ≤ 60, mmHg | 5 (8.2) | 6 (11.1) | 0.596 |
 Respiratory rate > 30 breaths per min | 2 (3.3) | 4 (7.4) | 0.320 |
Blood laboratory findings | Â | Â | Â |
 White blood cell count, ×109/L | 4.3 (3.5–5.1) | 5.4 (4.1–7.0) | < 0.0001 |
 Neutrophil count, ×109/L | 2.5 (2.1–3.5) | 3.0 (2.1–4.6) | 0.036 |
 Lymphocyte count, ×109/L | 1.0 (0.8–1.4) | 1.3 (1.0–1.9) | 0.011 |
 Monocyte count, ×109/L | 0.3 (0.2–0.4) | 0.3 (0.2–0.4) | 0.079 |
 NLR | 2.6 (1.6–3.5) | 2.3 (1.5–3.9) | 0.676 |
 C-reactive protein, mg/L | 12.0 (3.7–27.8) | 21.6 (1.9–87.4) | 0.184 |
 Hemoglobin, g/L | 138.0 (127.0–150.5) | 139.0 (127.8–147.0) | 0.773 |
 Platelet count, ×109/L | 164.0 (135.0–219.5) | 205.5 (149.8–263.6) | 0.013 |
 Prothrombin time, s | 12.0 (11.1–13.1) | 12.2 (11.8–13.1) | 0.191 |
 Potassium, mmol/L | 3.8 (3.5–4.1) | 3.8 (3.6–4.2) | 0.408 |
 Sodium, mmol/L | 139.0 (137.0–140.0) | 138.5 (136.4–139.7) | 0.112 |
 Serum Chlorine, mmol/L | 102.0 (100.0–104.0) | 102.3 (100.2–105.3) | 0.796 |
 Serum urea nitrogen, mmol/L | 4.3 (3.5–5.6) | 4.3 (3.4–5.5) | 0.989 |
 Creatinine, μmol/L | 60.0 (47.0–69.5) | 69.3 (51.6–80.1) | 0.069 |
 Serum glucose, mmol/L | 6.1 (5.5–6.9) | 5.9 (5.2–7.7) | 0.407 |
 Creatine kinase, U/L | 93.0 (57.0–137.0) | 89.4 (63.7–141) | 0.643 |
 Alanine aminotransferase, U/L | 19.0 (14.0–33.5) | 23.7 (13.9–35.4) | 0.295 |
 Albumin, g/L | 44.0 (40.5–47.0) | 41.1 (36.2–44.2) | 0.005 |
 Multiple lung lobe or bilateral involvement | 48 (78.7) | 37 (68.5) | 0.743 |
 With bacterial infection | 8 (13.1) | 6 (11.1) | 0.231 |
Timeline after onset of illness, median (range) | Â | Â | Â |
 Days from illness onset to admission time | 5 (0–23) | 7 (0–21) | 0.042 |
 Days from illness onset to dyspnea | 3 (2–11) | 7 (0–9) | 0.906 |
 Days from illness onset to ICU admission | 9 (2–14) | 10 (4–14) | 0.643 |
Treatment | Â | Â | Â |
 Antiviral therapy | 34 (55.7) | 36 (66.7) | 0.231 |
 Antibiotic therapy | 26 (42.6) | 21 (38.9) | 0.684 |
 Use of corticosteroid | 2 (3.3) | 3 (5.6) | 0.550 |
 Oxygen support | 20 (32.8) | 24 (44.4) | 0.199 |
  Nasal cannula | 15 (24.6) | 19 (35.2) |  |
  Non-invasive ventilation | 3 (4.9) | 2 (3.7) |  |
  Invasive mechanical ventilation | 2 (3.3) | 3 (5.6) |  |
 Nebulization inhalation | 52 (85.2) | 49 (90.7) | 0.368 |
Outcomes | Â | Â | Â |
 Dead | 0 (0) | 1 (1.9) | 0.286 |
 Transfer to ICU | 8 (13.1) | 6 (11.1) | 0.743 |
 Discharge | 3 (4.9) | 19 (35.2) | < 0.0001 |
 Hospitalization | 50 (82.0) | 28 (51.9) | 0.001 |