Fig. 5

Sepsis candidate lncRNAs. a Overview of the lncRNA-module network. The bottom panel illustrate the subnetwork of sepsis candidate lncRNAs and interacting modules. Up-regulated DEMs are colored in red, down-regulated DEMs are colored in blue, and SAMs are framed in red circle. The node size of modules corresponds to module size. b Module connectivity of lncRNAs. The pie plot indicates the proportion of lncRNAs with different connectivity. The bar plot shows the lncRNAs linking more than one module. c ceRNA regulatory mechanism in sepsis. Short curves represent miRNAs and ellipses stand for MREs of lncRNAs or gene transcripts. The lncRNA sharing MREs with a gene module were hypothesized to regulate the module by competing for microRNA binding. d ceRNA interactions. Red and blue lines indicate lncRNA-miRNA and miRNA-module interactions, respectively. Bold black line represents the competing endogenous relationship. e Secondary structure of FENDRR, MALAT1, TUG1, and CRNDE. f Description of the sepsis lncRNA candidates. ceRNA, competing endogenous RNA. MREs, miRNA response elements. DEMs, differentially expressed modules. SAMs, survival associated modules