Fig. 3

Combined residency and exhaustion signatures of CD8⁺dT cells. a GSEA analysis with gene sets of core T_RM signature, tumor-infiltrating monocytes and LCMV-specific exhausted CD8⁺T cells, respectively. NES, normalized enrichment score; FDR, false discovery rate; Nom, nominal. b Heat map of selected genes that are expressed differentially between CD8⁺dT cells and CD8⁺pT cells; gene expression was row normalized. c Representative FACS plots (Left) and percentages (Right) of the activation markers CD69, HLA-DR, tissue residency associated marker, CD103, CXCR3, and the coinhibitory molecule PD-1, as well as the CD39 molecule expressed on freshly isolated CD8⁺pT cells and CD8⁺dT cells. Graphs depict data of six to ten samples in each group; paired t⁻test, **p = < 0.01, ***p = < 0.005