Fig. 2
Primary outcome analysis of B cell density in prostatectomy tissue showed decrease in B-cell density in tumor regions after neoadjuvant Rituximab treatment. a Boxplot and scatter plot for B cell density (Treated vs. Control), B-cell density in treated: 0.027 mm2/mm2 (95% CI 0.021, 0.033) and 0.044 mm2/mm2 (95% CI 0.028, 0.062) in the controls, p = 0.02 for Welch two sample t-test comparing B-cell density of Tumor in treated group and historic control group, i.e. The mean B cell density in tumor was significantly lower in treated subjects compared to historical control subjects. C = control samples, P = PROTUX Rituximab-treated, T = marked tumor region, N = adjacent normal tissue. b Within subject difference of B-cell density: tumor minus adjacent normal tissue (Treated vs. Controls)