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Table 3 Multivariate Cox regression analyses of risk factors for overall survival

From: Development and validation of a hypoxia-immune-based microenvironment gene signature for risk stratification in gastric cancer

 

Adjusted Hazard ratioa

95% confidence interval

Adjusted p

Discovery cohort

 Risk group (High vs low)

3.24

2.03–5.18

< 0.001

 Tumor stage

< 0.001

  II vs I

1.35

0.48–3.81

0.574

  III vs I

3.37

1.24–9.17

0.017

TCGA cohort

 Risk group (High vs low)

2.91

1.76–4.80

< 0.001

 Tumor stage

< 0.001

  II vs I

1.91

0.93–3.92

0.076

  III vs I

3.04

1.54–6.01

0.001

  VI vs I

6.92

3.07–15.59

< 0.001

ACRG cohort

 Risk group (High vs low)

1.99

1.42–2.78

< 0.001

 Tumor stage

< 0.001

  II vs I

1.51

0.58–3.93

0.398

  III vs I

3.01

1.18–7.68

0.021

  VI vs I

8.83

3.50–22.28

< 0.001

CHEM cohort

 Risk group (High vs low)

3.01

1.56–5.83

0.001

 Tumor stage

0.012

  III vs II

2.20

1.04–4.64

0.039

  IV vs II

3.35

1.50–7.48

0.003

  1. aGender and age were adjusted for modelling using the discovery cohort; and gender, age and histology classification were adjusted when using TCGA, ACRG and CHEM cohorts
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Journal of Translational Medicine

ISSN: 1479-5876

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