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Table 3 Multivariate Cox regression analyses of risk factors for overall survival

From: Development and validation of a hypoxia-immune-based microenvironment gene signature for risk stratification in gastric cancer

  Adjusted Hazard ratioa 95% confidence interval Adjusted p
Discovery cohort
 Risk group (High vs low) 3.24 2.03–5.18 < 0.001
 Tumor stage < 0.001
  II vs I 1.35 0.48–3.81 0.574
  III vs I 3.37 1.24–9.17 0.017
TCGA cohort
 Risk group (High vs low) 2.91 1.76–4.80 < 0.001
 Tumor stage < 0.001
  II vs I 1.91 0.93–3.92 0.076
  III vs I 3.04 1.54–6.01 0.001
  VI vs I 6.92 3.07–15.59 < 0.001
ACRG cohort
 Risk group (High vs low) 1.99 1.42–2.78 < 0.001
 Tumor stage < 0.001
  II vs I 1.51 0.58–3.93 0.398
  III vs I 3.01 1.18–7.68 0.021
  VI vs I 8.83 3.50–22.28 < 0.001
CHEM cohort
 Risk group (High vs low) 3.01 1.56–5.83 0.001
 Tumor stage 0.012
  III vs II 2.20 1.04–4.64 0.039
  IV vs II 3.35 1.50–7.48 0.003
  1. aGender and age were adjusted for modelling using the discovery cohort; and gender, age and histology classification were adjusted when using TCGA, ACRG and CHEM cohorts