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Table 1 Baselines characteristics of participants

From: Clinical application and evaluation of metagenomic next-generation sequencing in suspected adult central nervous system infection

 CNS infection (159)Non-CNS infection (71)p value
CNS infection (n)
 Bacterial infection95
 Viral infection38
 Parasitic infection3
 Fungal infection10
 Mixed infectiona4
 Unclassified9
Non-CNS infection(n)
 Autoimmune encephalitis13
 Malignant tumor13
 Pulmonary diseases6
 Tsutsugamushi disease1
 Local infection7
 Blood-stream infection1
 Hematological disease3
 Rheumatic disease2
 Psychological disease1
 Fever of unknown origin7
 Other neurological diseaseb17
Gender(n)  0.791
 Male9742 
 Female6229 
Age, year (range)44.39 (13.00–73.00)42.30 (15.00–84.00)0.175
Body temperature, °C (Range)37.61 (36.20–40.70)37.47 (36.10–39.60)0.695
Empirical treatment history(n)  0.103
 Yes11960 
 No4011 
Blood laboratory examination (range)
 C-reaction protein, mg/L19.6 (3.0–126.0)32.8 (3.0–194.0)0.568
 Erythrocyte sedimentation rate, mm/h25.20 (2.00–137.00)26.07 (2.00–118.00)0.830
 Procalcitonin, ng/mL0.34 (0.01–4.90)0.19 (0.02–1.82)0.386
 Serum ferritin, ng/mL631.84 (14.46–2000.00)560.26 (64.92–1209.00)0.802
 WBC, *109/L8.84 (2.35–26.03)9.06 (2.87–27.60)0.347
 Neutrophil, %69.26 (26.00–95.70)79.11 (60.4–97.30)0.427
  1. Statistics: Chi-square for calculations of gender and empirical treatment history, Mann–Whitney test for comparisons in age, body temperature and blood laboratory examination
  2. aMixed pathogens: three patients were defined as bacterial and viral CNS co-infection, and another was defined as bacterial and fungal CNS co-infection
  3. b Other neurological disease: metabolic encephalopathy, hypertrophic cranial pachymeningitis, toxic encephalopathy,intracranial inflammatory granuloma, cerebral venous sinus thrombosis, spinal cord tumor, acute immune encephalomyelitis, acute disseminated encephalomyelitis, cerebral venous sinus thrombosis, demyelinating disease and peripheral neuropathy
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