Fig. 1

Streptozotocin (STZ) increases the severity of Sjögren’s syndrome (SS) in NOD/ShiLtJ mice. a After intraperitoneal injection of STZ (180 mg/kg) or vehicle into 10-week-old female NOD/ShiLtJ mice (n = 3 per group), the blood glucose level was determined using a glucometer. b Changes in body weight. c Salivary flow rates at 0, 7, and 11 days after injection of STZ. d Sections of parotid glands obtained 11 days after administration of STZ were stained with hematoxylin and eosin. Representative histological features and histologic grades are shown. ^***P < 0.001 vs. vehicle–treated group. Data are mean ± SD