Fig. 8

VE-cadherin expression in the renal cortex and lungs. a VE-cadherin immunostaining in the renal cortex of the WT sham, WT CLP and WT CLP R-954 groups. Specific fluorescence: green for VE-cadherin, orange for isolectin B4 (endothelial cell marker), blue for cell nuclei (DAPI). Scale: 50 µm. b Mean fluorescence intensity established for 10 fields selected randomly by slide, magnification ×400. A.U.: arbitrary unit; n = 7 to 11 per group. c VE-cadherin immunostaining in the lungs of the WT sham, WT CLP and WT CLP R-954 groups. Scale: 50 µm (optical microscope magnification ×400). d VE-cadherin expression in relation to the total immunostained surface area, established for 10 fields selected randomly by slide, with magnification ×400 (in %); n = 7 to 10 per group. WT sham: sham-operated C57BL/6J controls; WT CLP: CLP-induced septic C57BL/6J mice; WT CLP R-954: CLP-induced septic C57BL/6J mice that received prophylactic B1R antagonist R-954. Kruskal–Wallis test followed by a Dunn’s correction *p < 0.05; ***p < 0.001; ****p < 0.0001. Results expressed in median ± IQR