Fig. 6

Examples of integrated neutrophil chemotaxis devices combined with cell culture units. A Microfluidic device that combines multiple networks and cell culture chamber where the stable gradient is generated. Reprinted with permission from Ref. [80], copyright (2012) American Chemical Society; B schematic diagram of microfluidic transwell insert. The device hangs self-supporting in a 6-well. The concentration gradient is generated in the external fluid space (color map) between the track-etched membrane (green line) and the cell culture surface that is approximately 250 µm in height. Reprinted from Ref. [78], Copyright (2014), with permission from The Royal Society of Chemistry, permission conveyed through Copyright Clearance Center, Inc