Fig. 3From: High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injuryHMGB1 impaired the therapeutic effects of MSCs on renal IRI in mice. Mice were subjected to 30 min bilateral renal IRI and then received differently treated-MSCs (1 × 106) via the tail vein 2 h after reperfusion. Mice were sacrificed at day 1 to collect blood and kidney tissues. a Serum levels of Scr and BUN were detected as kidney function. b Representative images of H&E staining are exhibited and ATN scores were calculated. c Representative photographs of TUNEL staining are demonstrated and quantitative analysis of TUNEL-positive cells was performed. Data were shown as mean ± SD (n = 6 mice per group). *P < 0.05Back to article page