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Table 2 GO and KEGG pathway enrichment analysis of AAGs in lung adenocarcinoma

From: Development and validation of a survival model for lung adenocarcinoma based on autophagy-associated genes

TermsPathway IDPathway descriptionGeneIDCountFDR
BPGO:0050873Brown fat cell differentiationBNIP3/ERO1A20.04082
GO:0010660Regulation of muscle cell apoptotic processBNIP3/IFNG/CDKN2A30.02240
GO:0097193Intrinsic apoptotic signaling pathwayDAPK2/PPP1R15A/PARP1/P4HB/IKBKE/BNIP3/ERO1A70.00011
GO:0001953Negative regulation of cell–matrix adhesionDLC1/CDKN2A20.04082
GO:0052548Regulation of endopeptidase activityDLC1/NLRC4/GAPDH/BIRC540.04616
GO:0052547Regulation of peptidase activityDLC1/NLRC4/GAPDH/BIRC540.04990
GO:0034599Cellular response to oxidative stressFOS/PARP1/P4HB/BNIP3/ERO1A50.00916
GO:0061919Process utilizing autophagic mechanismHSPB8/DAPK2/MAP1LC3C/BNIP3/IFNG/VMP1/ITGB4/GAPDH/ATG9B/TMEM74100.00000
GO:0016236MacroautophagyHSPB8/MAP1LC3C/BNIP3/VMP1/GAPDH/ATG9B/TMEM7470.00011
GO:0035967Cellular response to topologically incorrect proteinHSPB8/PPP1R15A/CCL2/HSPA5/ERO1A50.00066
GO:0006986Response to unfolded proteinHSPB8/PPP1R15A/CCL2/HSPA5/ERO1A50.00118
GO:0001558Regulation of cell growthNRG3/PRKCQ/ERBB2/CDKN2A40.04988
GO:0006575Cellular modified amino acid metabolic processP4HB/ATIC/ERO1A30.04632
GO:0071456Cellulaar response to hypoxiaP4HB/BNIP3/EIF4EBP1/ERO1A40.01895
GO:00194714-hydroxyproline metabolic processP4HB/ERO1A20.00966
GO:0030968Endoplasmic reticulum unfolded protein responsePPP1R15A/CCL2/HSPA5/ERO1A40.00411
GO:0034976Response to endoplasmic reticulum stressPPP1R15A/CCL2/HSPA5/P4HB/ERO1A50.00551
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressPPP1R15A/ERO1A20.04990
CCGO:0005776AutophagosomeDAPK2/MAP1LC3C/VMP1/ATG9B/TMEM7450.00001
GO:0000421Autophagosome membraneMAP1LC3C/VMP1/ATG9B/TMEM7440.00001
MFGO:0019887Protein kinase regulator activityNRG3/NRG1/CDKN2A30.03024
KEGG Pathwayshsa04140Autophagy-animalVMP1/DAPK2/BNIP3/ATG9B/PRKCQ50.00940
hsa04012ErbB signaling pathwayNRG1/ERBB2/NLRC4/EIF4EBP140.01011
hsa04657IL-17 signaling pathwayCCL2/IFNG/ITGB4/FOS40.01011
hsa05219Bladder cancerDAPK2/CDKN2A/ERBB230.01028
hsa04066HIF-1 signaling pathwayIFNG/ERO1A/GAPDH/EIF4EBP140.01071
hsa05323Rheumatoid arthritisCCL2/ITGB4/FOS30.03726
hsa01524Platinum drug resistanceBIRC5/CDKN2A/ERBB230.03236
hsa04141Protein processing in endoplasmic reticulumERO1A/P4HB/PPP1R15A/HSPA540.03236
hsa01521EGFR tyrosine kinase inhibitor resistanceNRG1/ERO1A/EIF4EBP130.03236
hsa05132Salmonella infectionNLRC4/IFNG/FOS30.03236
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancerIFNG/FOS/CDKN2A30.03726
hsa01522Endocrine resistanceCDKN2A/FOS/ERBB230.03988
hsa05142Chagas disease (American trypanosomiasis)CCL2/IFNG/FOS30.04085
hsa04660T cell receptor signaling pathwayIFNG/FOS/NLRC430.04085
hsa04659Th17 cell differentiationIFNG/PRKCQ/NLRC430.04147
  1. GO gene ontology, KEGG Kyoto encyclopedia of genes and genomes, AAG autophagy-associated genes, FDR false discovery rate
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