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Table 6 Multivariate COX regression analysis of composite MACCE

From: Real-world use of ACEI/ARB in diabetic hypertensive patients before the initial diagnosis of obstructive coronary artery disease: patient characteristics and long-term follow-up outcome

 

Univariate

Multivariate

HR(95%CI)

P value

Adjusted HR(95%CI)

P value

Age,y

1.01 (0.99, 1.02)

NS

1.00 (0.99, 1.01)

NS

Male, %

1.05 (0.89, 1.25)

NS

1.05 (0.82, 1.33)

NS

ACEI/ARB(-)

1.21 (1.02, 1.43)

< 0.05

1.24 (1.04, 1.48)

< 0.05

Previous stroke

1.57 (1.29, 1.90)

< 0.001

1.49 (1.22, 1.82)

< 0.001

Smoking

1.09 (0.93, 1.29)

NS

1.05 (0.85, 1.31)

NS

Hemoglobin, g/L

1.00 (0.99, 1.00)

NS

0.99 (0.98, 1.00)

NS

Glycated hemoglobin, %

1.08 (1.02, 1.14)

< 0.05

1.05 (0.99, 1.11)

NS

LDL-C, mmol/L

1.15 (1.03, 1.28)

< 0.05

1.07 (0.95, 1.20)

NS

eGFR ml/min/1.73 m2

0.98 (0.97, 0.99)

< 0.001

0.98 (0.97, 0.99)

< 0.05

AMI at admission

1.62 (1.36, 1.93)

< 0.001

1.18 (0.96, 1.45)

NS

LVEF, %

0.97 (0.96, 0.98)

< 0.001

0.98 (0.97, 0.99)

< 0.001

Involved vessel

1.45 (1.29, 1.62)

< 0.001

1.34 (1.19, 1.51)

<0.001

CTO

1.49 (1.23, 1.81)

< 0.001

1.07 (0.87, 1.33)

NS

In-hospital treatment

Antiplatelet agents

0.45 (0.33, 0.63)

< 0.001

0.45 (0.31, 0.65)

< 0.001

ACEI/ARB

0.92 (0.78, 1.09)

NS

1.00 (0.84, 1.19)

NS

Beta-blocker

0.93 (0.78, 1.12)

NS

0.87 (0.72, 1.06)

NS

Statins

0.75 (0.58, 0.95)

<0.05

0.94 (0.72, 1.23)

NS

  1. ACEI/ARB(-) no angiotensin-converting enzyme inhibitor/angiotensin receptor blocker therapy before admission, LDL-C low-density lipoprotein cholesterol, eGFR estimated glomerular filtration rate, AMI acute myocardial infarction, LVEF left ventricular ejection fraction, CTO chronic total occlusions; NS non-significant