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Table 2 Multivariate Cox regression analysis of overall survival in each dataset

From: An integrated prognosis model of pharmacogenomic gene signature and clinical information for diffuse large B-cell lymphoma patients following CHOP-like chemotherapy

 

Multivariate analysis

HR

95% CI

p value

Training cohort

 GSE31312 (n = 449)

  Age

1.03

1.01–1.04

1.38 × 10−5

  Extra nodal sites number

1.20

1.03–1.41

2.37 × 10−2

  Stage

1.31

1.12–1.52

6.26 × 10−5

  ECOGa

1.41

1.21–1.64

7.33 × 10−6

  Resistance probability of doxorubicin

2.70

1.24–5.86

1.23 × 10−2

  Resistance probability of vincristine

1.28

0.61–2.70

0.51

Validating cohort

 GSE10846 (n = 342)

  Age

1.02

1.01–1.04

1.45 × 10−4

  Extra nodal sites number

0.99

0.80–1.22

0.95

  Stage

1.41

1.19–1.67

5.40 × 10−5

  ECOGa

1.59

1.32–1.91

6.43 × 10−7

  Resistance probability of doxorubicin

3.24

1.41–7.45

5.61 × 10−3

  Resistance probability of vincristine

1.40

0.61–3.23

0.43

  1. HR hazard ratio, 95% CI 95% confidence interval
  2. aThe Eastern Cooperative Oncology Group (ECOG) performance score ranges from 0 to 3, with a higher score indicating greater impairment