Table 5 Univariate and multivariate analysis with progression-free survival
From: The effect of smoking on biological change of recurrent breast cancer
Parameters | Univarite analysis | Multivarite analysis | ||||
|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | p value | Hazard ratio | 95% CI | p value | |
Age at operation (years old) | ||||||
 ≤ 60 vs > 60 | 1.871 | 0.716–5.172 | 0.201 |  |  |  |
Tumor size (cm) | ||||||
 ≤ 21.8 vs > 21.8 | 1.708 | 0.654–4.714 | 0.274 |  |  |  |
Lymph node metastasis | ||||||
 Negative vs positive | 2.503 | 0.794–6.779 | 0.110 |  |  |  |
Estrogen receptor (ER) of primary tumor | ||||||
 Negative vs positive | 0.753 | 0.264–2.690 | 0.631 |  |  |  |
Progesterone receptor (PgR) of primary tumor | ||||||
 Negative vs positive | 0.296 | 0.555–1.765 | 0.296 |  |  |  |
HER2 of primary tumor | ||||||
 Negative vs positive | 3.571 | 0.190–20.270 | 0.310 |  |  |  |
Ki67 of primary tumor | ||||||
 ≤ 14% vs > 14% | 0.726 | 0.276–2.017 | 0.525 |  |  |  |
Intrinsic subtype HRBC | ||||||
 No vs Yes | 0.574 | 0.198–2.068 | 0.363 |  |  |  |
Intrinsic subtype HER2BC | ||||||
 No vs yes | 3.571 | 0.190–20.270 | 0.310 |  |  |  |
Intrinsic subtype TNBC | ||||||
 No vs yes | 1.394 | 0.318–4.345 | 0.618 |  |  |  |
Chemotherapy after surgery | ||||||
 No/yes | 3.734 | 1.316–10.115 | 0.015 | 2.953 | 0.844–9.775 | 0.088 |
Endocrine therapy after surgery | ||||||
 No vs yes | 0.650 | 0.240–2.049 | 0.435 |  |  |  |
Radiation therapy after surgery | ||||||
 No vs yes | 1.352 | 0.429–3.654 | 0.581 |  |  |  |
Trastuzumab after surgery | ||||||
 No vs yes | 13.762 | 0.680–107.629 | 0.077 | 7.081 | 0.323–67.456 | 0.172 |
No-treatment after surgery | ||||||
 No vs yes | 0.502 | 0.028–2.486 | 0.461 |  |  |  |
Age at recurrence (years old) | ||||||
 ≤ 62 vs > 62 | 1.690 | 0.639–4.557 | 0.287 |  |  |  |
Recurrence site biopsied | ||||||
 Local, regional lymph node vs distant metastasis | 2.225 | 0.347–8.089 | 0.340 |  |  |  |
Change of ER in recurrence | ||||||
 The other vs negative conversion | 3.228 | 0.503–11.746 | 0.182 |  |  |  |
Change of PgR in recurrence | ||||||
 No change vs negative conversion | 1.070 | 0.383–2.827 | 0.892 |  |  |  |
Change of HER2 in recurrence | ||||||
 No change vs positive conversion | 1.423 | 0.324–4.485 | 0.599 |  |  |  |
Change of intrinsic subtype in recurrent tumor | ||||||
 No vs yes | 3.889 | 1.083–11.236 | 0.039 | 3.645 | 0.910–12.622 | 0.066 |
Disease free survival | ||||||
 ≤ 792 vs > 792 | 0.697 | 0.250–1.852 | 0.469 |  |  |  |
Smoker | ||||||
 No vs yes | 0.312 | 0.049–1.109 | 0.075 | 0.273 | 0.042–1.003 | 0.051 |