Fig. 5

Study design for the lentiviral based MJD model. Twenty-five C57/Bl6 mice, males, 8 weeks old, were stereotaxically-injected in the striatum with lentiviral vectors encoding mutant human ataxin-3 with 72 CAG repeats. Mice were then randomly distributed into treatment (n = 12) and control groups (n = 13) that received either 2% Trehalose in drinking water or fresh distilled water, respectively, After 2 and 4 weeks of drug administration, mice were euthanized and brains collected for analysis