High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?

Table 1 Physical and fitness characteristics of the participants

Characteristics	Group 1 (n = 6)	Group 2 (n = 6)	Total (n = 12)
Sex	3 females, 3 males	3 females, 3 males	6 females, 6 male
Age (years)	22.50 ± 2.07	25.67 ± 4.46	24.08 ± 3.70
Height (cm)	180.33 ± 10.41	175.17 ± 5.15	177.75 ± 8.28
Mass (kg)	77.78 ± 26.34	80.05 ± 13.31	78.92 ± 19.93
BMI (kg/m²)	23.44 ± 4.82	26.04 ± 4.09	24.73 ± 4.47
Fitness level (IPAQ-score)	4 moderate, 2 high	4 moderate, 2 high	8 moderate, 4 high
Individual performance limit (W)	221.20 ± 36.27	236.50 ± 41.20	228.83 ± 37.90
Individual performance limit (W/kg)	2.97 ± 0.69	2.9 ± 0.50	2.93 ± 0.57

Each donor executed the two exercise protocols in crossover fashion. At the first visit (week 1), one group (n = 6, group 1) performed a single bout of continuous exercise (CONT) at 50% P_max for 30 min, while the other group (n = 6, group 2) performed a single bout of high-intensity interval training (20 min of 30-s 100% P_max intervals each followed by a 30-s pause 5 min before and after HIT exercises at 50% P_max, more precisely High Intensity High Volume Training, HIHVT). At the second visit (week 3), each group switched over to the other exercise protocol. In other words, group 1 did continuous exercise during the first visit now and did HIT exercise on the second (CONT/HIT), and group 2 vice versa (HIT/CONT)

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