P-selectin blockade ameliorates lupus nephritis in MRL/lpr mice through improving renal hypoxia and evaluation using BOLD-MRI

Table 1 Urinary protein alteration in MRL/lpr mice with normal saline or anti-P-selectin monoclonal antibody treatment

	24-h urinary protein (mg)			Urinary protein concentration (mg/mL)			Urinary ACR (mg/mmol)
	12 wks	16 wks	20 wks	12 wks	16 wks	20 wks	12 wks	16 wks	20 wks
Norma saline treatment
A1	3.24 ± 1.47	4.22 ± 1.71	–	1.60 ± 0.82	2.70 ± 1.38**	–	4.36 ± 3.19	5.78 ± 4.43	–
B1	3.0 ± 1.71	4.08 ± 1.83	4.2 ± 5.95	1.63 ± 1.02	2.50 ± 1.39	2.79 ± 1.89	3.39 (2.74,6.32)	3.34 (2.78, 6.74)	5.02 (2.8, 33.77)
Anti-P-selectin mAb treatment
A2	1.83 ± 0.83	1.19 ± 0.58^#	–	1.57 ± 0.60	2.56 ± 1.55	–	2.69 ± 0.45	1.14 ± 0.10*	–
B2	3.67 ± 2.22	1.69 ± 0.89^##	2.14 ± 1.41^▲	1.94 ± 0.82	2.16 ± 0.80	3.30 ± 1.06	2.36 (2.14,3.11)	2.68 (1.24,3.21)	2.35 (2.0, 8.65)^▲
C2	–	3.75 ± 1.99	3.94 ± 3.17	–	2.80 ± 0.47	3.58 ± 0.74	–	2.35 (2.0, 8.65)	10.07 (2.54,12.59)

The results are presented as the mean ± SD or median (first quartile, third quartile). Saline groups:A1 and B1 groups were treated with normal saline from 12 to 16 weeks and from 12 to 20 weeks, respectively. Anti-P-selectin groups: A2, B2, and C2 groups were treated with anti-P-selectin mAb from 12 to 16 weeks, from 12 to 20 weeks, and from 16 to 20 weeks, respectively
Compared with the baseline (that in 12 weeks for the same group), *, **P < 0.05. Compared with the same age saline group, ^#, ^##P < 0.05. Compared with the C2 group, ^▲P < 0.05

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