Fig. 7

Role of mitophagy in the protective effect of PD against sepsis-induced NLRP3 activation. The mice were subjected to CLP and administered vehicle, PD (30 mg/kg), or PD along with mdivi-1 (3 mg/kg). Parkin−/− mice were subjected to CLP and administered PD (30 mg/kg). The mice were sacrificed at 12 h after CLP. a The expression of NLRP3, ASC, pro-caspase-1, caspase-1 p10, pro-IL-1 and IL-1β was measured by western blot analysis. Quantification of b NLRP3, c ASC, d pro-caspase-1, e caspase-1 p10, f pro-IL-1, and g IL-1β. h IL-1β in the kidney was measured by ELISA