Table 2 The evidence quality for thiazide diuretics reducing the incidence of kidney stones and 24-h urinary calcium level
Quality assessment | No of patients | Effect | Quality | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | UCa of thiazide diuretics | Placebo | Relative (95% CI) | Absolute | ||
Thiazide diuretics VS placebo in 24-h UCa | ||||||||||||
4 | Randomized trials | No serious risk of bias | No serious inconsistency | No serious indirectness | Seriousa | None | 145 | 171 | – | SMD 18.59 lower (25.11 to 12.08 lower) | Moderate | Important |
Thiazide diuretics VS placebo in incidence of new kidney stones | ||||||||||||
8 | Randomized trials | No serious risk of bias | Seriousb | No serious indirectness | Seriousa | None | 52/286 (18.2%) | 119/285 (41.8%) | – | 418 fewer per 1000 (from 418 fewer to 418 fewer) | Low | Critical |