From: Clinical, pathological and dermoscopic phenotype of MITF p.E318K carrier cutaneous melanoma patients
 | N |  | MITF+ N (%) | MITF− N (%) | ORa | Lower CI | Upper CI | p-value |
---|---|---|---|---|---|---|---|---|
Phototype | 927 | I | 0 (0) | 52 (6) | Â | Â | Â | 0.27 |
II | 15 (75) | 478 (53) | Â | Â | Â | Â | ||
III | 5 (25) | 353 (39) | Â | Â | Â | Â | ||
IV | 0 (0) | 24 (3) | Â | Â | Â | Â | ||
Freckles | 349 | None | 8 (4) | 77 (23) | Â | Â | Â | 0.37 |
Rare | 4 (2) | 126 (38) | Â | Â | Â | Â | ||
Few | 7 (35) | 89 (27) | Â | Â | Â | Â | ||
Many | 1 (5) | 37 (11) | Â | Â | Â | Â | ||
Hair color | 932 | Albino | 0 (0) | 1 (0) | Â | Â | Â | 0.06 |
Red | 1 (5) | 49 (5) | Â | Â | Â | Â | ||
Blond | 9 (43) | 201 (22) | Â | Â | Â | Â | ||
Blond_red | 0 (0) | 9 (1) | Â | Â | Â | Â | ||
Brown | 7 (33) | 565 (62) | Â | Â | Â | Â | ||
Black | 4 (19) | 86 (9) | Â | Â | Â | Â | ||
Eye color | 931 | Light blue | 7 (37) | 214 (23) | Â | Â | Â | 0.50 |
Blue | 1 (5) | 38 (4) | Â | Â | Â | Â | ||
Green | 2 (11) | 98 (11) | Â | Â | Â | Â | ||
Grey | 0 (0) | 21 (2) | Â | Â | Â | Â | ||
Light brown | 1 (5) | 206 (23) | Â | Â | Â | Â | ||
Dark brown | 8 (42) | 324 (36) | Â | Â | Â | Â | ||
Black | 0 (0) | 5 (1) | Â | Â | Â | Â | ||
Hazel | 0 (0) | 6 (1) | Â | Â | Â | Â | ||
Number of nevi | 492 | < 10 | 3 (17) | 200 (42) |  |  |  | 0.04 |
10–50 | 10 (55) | 185 (39) |  |  |  |  | ||
> 50 | 5 (28) | 89 (19) |  |  |  |  | ||
Histologically diagnosed Dysplastic nevi | 866 | Median (IQR) | 0 (0–1) | 0 (0–0) |  |  |  | < 0.001 |
0 | 10 (50) | 769 (91) | 9.93 | 3.59 | 27.53 | < 0.001 | ||
1+ | 10 (50) | 77 (9) | Â | Â | Â | Â | ||
Familial | 984 | Spo | 17 (77) | 833 (87) | 1.9 | 0.54 | 5.48 | 0.21 |
Fam | 5 (23) | 129 (13) | Â | Â | Â | Â | ||
Age at first melanoma | 858 | Median (IQR) | 44 (32.25–58.75) | 49 (38.99–61.71) |  |  |  | 0.20 |
N. of melanomas removed | 983 | Median (IQR) | 1 (1–1.75) | 1 (1–1) |  |  |  | 0.02 |
1 | 16 (73) | 855 (89) | 3.02 | 0.95 | 8.35 | 0.03 | ||
2+ | 6 (27) | 106 (11) | Â | Â | Â | Â | ||
Breslow mm | 930 | Median (IQR) | 1 (0.6–2.025) | 1 (0.35–1.765) |  |  |  | 0.22 |
Sentinel node | 337 | Neg | 6 (27) | 266 (28) | 1.41 | 0.14 | 8.1 | 0.65 |
Pos | 2 (9) | 63 (7) | Â | Â | Â | Â | ||
Stage | 771 | IS | 2 (17) | 122 (16) | Â | Â | Â | 0.65 |
I | 8 (67) | 473 (62) | Â | Â | Â | Â | ||
II | 2 (17) | 75 (10) | Â | Â | Â | Â | ||
III | 0 (0) | 56 (7) | Â | Â | Â | Â | ||
IV | 0 (0) | 33 (4) | Â | Â | Â | Â | ||
Pancreatic cancer in family | 972 | No | 19 (86) | 901 (94) | 2.90 | 0.53 | 10.35 | 0.11 |
Yes | 3 (14) | 49 (5) | Â | Â | Â | Â | ||
Kidney cancer in family | 971 | No | 18 (82) | 910 (95) | 5.17 | 1.21 | 16.74 | 0.01 |
Yes | 4 (18) | 39 (5) | Â | Â | Â | Â | ||
Site of first melanoma | 943 | Head and neck | 1 (5) | 74 (8) | Â | Â | Â | 0.27 |
Trunk | 8 (40) | 464 (50) | Â | Â | Â | Â | ||
Arms | 6 (30) | 125 (14) | Â | Â | Â | Â | ||
Legs | 5 (25) | 260 (28) | Â | Â | Â | Â | ||
Histotype of first melanoma | 722 | Acral | 2 (9) | 11 (2) | Â | Â | Â | 0.04 |
Lentigo maligna | 0 (0) | 36 (5) | Â | Â | Â | Â | ||
Nodular | 7 (32) | 132 (19) | Â | Â | Â | Â | ||
SSM | 13 (59) | 454 (64) | Â | Â | Â | Â | ||
Other | 0 (0) | 67 (10) | Â | Â | Â | Â | ||
MC1R | 576 | –/– | 6 (30) | 165 (30) |  |  |  | 0.45 |
r/– | 4 (20) | 158 (28) |  |  |  |  | ||
r/r | 2 (10) | 24 (4) | Â | Â | Â | Â | ||
R/– | 6 (30) | 111 (21) |  |  |  |  | ||
R/r | 1 (5) | 74 (13) | Â | Â | Â | Â | ||
R/R | 1 (5) | 24 (4) | Â | Â | Â | Â |