Fig. 3
From: Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer
The main targets of ZEB1 and the processes involved in breast cancers. Cyclin-dependent protein kinase-like 2(CDKL2) transcriptionally activates ZEB1 and suppresses E-cadherin to promote the EMT process. The carcinogenesis-related CSC state is determined by the CD44s isoform conserved by CD44v and controlled by epithelial splicing regulatory protein 1 (ESRP1). The transcriptional suppression of downstream LLGL1/2 by ZEB1 is associated with apical-basal polarity, and inhibition of ER-α by ZEB1 regulates the sensitivities to antiestrogen treatment in breast cancer. However, ZEB1 also transcriptionally activates the expression of ATM kinase and promotes the occurrence of chemoresistance