Metabolic classification of circulating tumor cells as a biomarker for metastasis and prognosis in breast cancer

Table 2 Cox regression analysis of PFS in BC patients

Variables	Hazard ratio	95% CI	P^a
Age, years (> 50 vs. ≤ 50)	1.83	0.62–5.37	0.27
Tumor size, cm (> 5 vs. ≤ 5)	1.23	0.38–3.98	0.73
Grading (III vs. I–II)	1.32	0.46–3.77	0.61
Distant metastasis (yes vs. no)	3.93	1.31–11.77	0.014*
Clinical stage (III–IV vs. I–II)	2.28	0.64–8.22	0.21
tCTCs (P vs. N)^b	3.69	1.03–13.28	0.046*
E-CTCs (P vs. N)	1.21	0.38–3.88	0.74
H-CTCs (P vs. N)	1.75	0.61–5.08	0.30
M-CTCs (P vs. N)	5.77	1.61–20.74	0.007**
GM⁺CTCs (P vs. N)	5.47	1.71–17.46	0.004**

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