Table 3 KEGG pathway enrichment analysis of CDKN3-related genes
Gene set name | Count | p-value | Genes |
|---|---|---|---|
Cell cycle | 41 | 9.93E−33 | E2F1, E2F2, CDC14B, DBF4, PKMYT1, TTK, PTTG2, CHEK1, PTTG1, CCNE2, CCNE1, CDC45, MCM7, CDKN2C, BUB1, ORC6, CCNA2, ORC1, CDC7, CDK1, CDC6, ESPL1, CDC20, MCM2, CDK4, CDC25C, MCM3, MCM4, MCM5, CDK2, CDC25A, MCM6, CDC25B, CCNB1, CCNB2, MAD2L1, PLK1, PCNA, BUB1B, ANAPC7, SMC1B |
DNA replication | 22 | 3.25E−24 | LIG1, POLA1, POLA2, MCM2, RNASEH2A, MCM3, MCM4, MCM5, MCM6, RFC5, POLD3, PRIM1, DNA2, RFC3, RFC4, MCM7, POLE2, RFC2, POLD1, PRIM2, PCNA, FEN1 |
Oocyte meiosis | 23 | 2.35E−13 | CDK1, CPEB3, PKMYT1, AURKA, PTTG2, CDC20, ESPL1, PTTG1, CDC25C, PPP1CC, CDK2, CCNB1, CCNE2, CCNE1, MAD2L1, CCNB2, SGO1, PLK1, BUB1, FBXO43, FBXO5, ANAPC7, SMC1B |
Mismatch repair | 11 | 2.00E−10 | EXO1, RFC5, POLD3, MSH6, RFC3, RFC4, RFC2, MSH2, LIG1, POLD1, PCNA |
Fanconi anaemia pathway | 13 | 1.65E−08 | RAD51C, BLM, EME1, FAAP24, RMI2, BRCA1, RAD51, FANCI, FANCD2, FANCE, FANCG, UBE2T, FANCB |
Homologous recombination | 10 | 5.51E−08 | POLD3, RAD51C, XRCC3, XRCC2, BLM, POLD1, EME1, RAD54B, RAD54L, RAD51 |
Progesterone-mediated oocyte maturation | 14 | 3.80E−06 | CCNB1, CDK1, MAD2L1, CCNB2, PLK1, CPEB3, BUB1, PKMYT1, ANAPC7, CDC25C, CCNA2, CDC25A, CDK2, CDC25B |
Spliceosome | 8 | 7.94E−07 | SNRPA1, ALYREF, SNRPD1, SF3A2, SF3B4, RBMX, HNRNPU, SRSF3, HNRNPA3, SRSF9, USP39, SNRPB, SNRPA, SNRPF, THOC1,SNRPG, RBM17 |