The prognostic value of a seven-lncRNA signature in patients with esophageal squamous cell carcinoma: a lncRNA expression analysis

Table 4 Univariate and multivariable Cox analysis of the effects of 7-lncRNA signature and clinical characteristics on disease-free survival in the independent cohort

Variables	Univariable analysis		Multivariable analysis
Variables	HR (95% CI)	p value	HR (95% CI)	p value
Training cohort
Age (≤ 59 vs > 59)	0.96 (0.65–1.48)	0.906
Gender (Male vs female)	0.78 (0.46–1.32)	0.357
Tobacco use (Y vs N)	1.30 (0.82–2.05)	0.265
Alcohol use (Y vs N)	1.10 (0.73–1.67)	0.657
Tumor location (U vs M vs L)	1.26 (0.86–1.85)	0.238
Differentiation (H vs Mt vs L)	2.49 (1.63–3.81)	< 0.001	2.23 (1.45–3.44)	< 0.001
TNM stage (III vs I, II)	2.41 (1.57–3.70)	< 0.001	1.93 (1.24–3.01)	0.003
LncRNA signature (H-risk vs L- risk)	2.36 (1.41–3.95)	< 0.001	2.28 (1.36–3.82)	0.002
Independent cohort
Age (≤ 59 vs > 59)	1.04 (0.64–1.70)	0.868
Gender (Male vs female)	1.14 (0.67–1.95)	0.632
Tobacco use (Y vs N)	1.03 (0.62–1.73)	0.901
Alcohol use (Y vs N)	1.05 (0.63–1.73)	0.858
Tumor location (U vs M vs L)	0.98 (0.64–1.51)	0.941
Differentiation (H vs Mt vs Low)	1.33 (0.94–1.89)	0.104
TNM stage (III vs I, II)	2.66 (1.60–4.40)	< 0.001	2.58 (1.55–4.27)	< 0.001
LncRNA signature (H-risk vs L-risk)	2.36 (1.41–3.95)	0.001	2.28 (1.36–3.82)	0.002

Y yes, N no, U upper, M middle, L low, H high, Mt moderate, H-risk high-risk, L-risk low-risk

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